Open Close
Reference
Citation
Wagner, C., Isermann, K., Roeder, T. (2009). Infection induces a survival program and local remodeling in the airway epithelium of the fly.  FASEB J. 23(7): 2045--2054.
FlyBase ID
FBrf0215395
Publication Type
Research paper
Abstract

Although the prevalence of inflammatory airway diseases is steadily growing, our knowledge regarding the underlying molecular and cellular mechanisms is fragmentary. The striking simplicity of the fruit fly's airway epithelium, which is composed of epithelial cells only, justifies its use as a model to study general features and response characteristics of airway epithelia in general. Infection with the gram-negative pathogen Erwinia carotovora induces an immune response in all epithelial cells via activation of the immune deficiency (IMD) pathway, but the transcriptional profile differs significantly from that observed after ectopic activation of this signaling pathway. After strong infections, genes controlling central aspects of tracheal development are reactivated, a response that is not seen after ectopic IMD pathway activation. Presumably to counteract infection-induced cell death-promoting signals, a survival response is launched, characterized by the concurrent expression and activation of the longevity genes dfoxo and dthor. Regions of the airways featuring the strongest immune reactions show substantial remodeling, which is characterized by a significant thickening of the epithelial cells. In conclusion, features related to those observed in inflammatory diseases of the human airways are apparently part of the normal response repertoire of airway epithelia to infection.

PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    FASEB J.
    Title
    FASEB Journal (Federation of American Societies for Experimental Biology)
    Publication Year
    1987-
    ISBN/ISSN
    0892-6638
    Data From Reference
    Alleles (5)
    Genes (35)
    Natural transposons (1)
    Insertions (1)
    Experimental Tools (2)
    Transgenic Constructs (4)