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Citation
Silbering, A.F., Rytz, R., Grosjean, Y., Abuin, L., Ramdya, P., Jefferis, G.S., Benton, R. (2011). Complementary Function and Integrated Wiring of the Evolutionarily Distinct Drosophila Olfactory Subsystems.  J. Neurosci. 31(38): 13357--13375.
FlyBase ID
FBrf0215822
Publication Type
Research paper
Abstract

To sense myriad environmental odors, animals have evolved multiple, large families of divergent olfactory receptors. How and why distinct receptor repertoires and their associated circuits are functionally and anatomically integrated is essentially unknown. We have addressed these questions through comprehensive comparative analysis of the Drosophila olfactory subsystems that express the ionotropic receptors (IRs) and odorant receptors (ORs). We identify ligands for most IR neuron classes, revealing their specificity for select amines and acids, which complements the broader tuning of ORs for esters and alcohols. IR and OR sensory neurons exhibit glomerular convergence in segregated, although interconnected, zones of the primary olfactory center, but these circuits are extensively interdigitated in higher brain regions. Consistently, behavioral responses to odors arise from an interplay between IR- and OR-dependent pathways. We integrate knowledge on the different phylogenetic and developmental properties of these receptors and circuits to propose models for the functional contributions and evolution of these distinct olfactory subsystems.

PubMed ID
PubMed Central ID
PMC6623294 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Neurosci.
    Title
    Journal of Neuroscience
    Publication Year
    1981-
    ISBN/ISSN
    0270-6474 1529-2401
    Data From Reference
    Alleles (24)
    Genes (23)
    Sequence Features (7)
    Natural transposons (1)
    Experimental Tools (3)
    Transgenic Constructs (20)
    Transcripts (13)