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Citation
Smith, C.D., Shu, S., Mungall, C.J., Karpen, G.H. (2007). The Release 5.1 annotation of Drosophila melanogaster heterochromatin.  Science 316(5831): 1586--1591.
FlyBase ID
FBrf0216199
Publication Type
Research paper
Abstract

The repetitive DNA that constitutes most of the heterochromatic regions of metazoan genomes has hindered the comprehensive analysis of gene content and other functions. We have generated a detailed computational and manual annotation of 24 megabases of heterochromatic sequence in the Release 5 Drosophila melanogaster genome sequence. The heterochromatin contains a minimum of 230 to 254 protein-coding genes, which are conserved in other Drosophilids and more diverged species, as well as 32 pseudogenes and 13 noncoding RNAs. Improved methods revealed that more than 77% of this heterochromatin sequence, including introns and intergenic regions, is composed of fragmented and nested transposable elements and other repeated DNAs. Drosophila heterochromatin contains "islands" of highly conserved genes embedded in these "oceans" of complex repeats, which may require special expression and splicing mechanisms.

PubMed ID
PubMed Central ID
PMC2819280 (PMC) (EuropePMC)
Related Publication(s)
Erratum

The release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith, 2007, Science 317(5843): 1325 [FBrf0201089]

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Secondary IDs
  • FBrf0202564
Language of Publication
English
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Parent Publication
Publication Type
Journal
Abbreviation
Science
Title
Science
Publication Year
1895-
ISBN/ISSN
0036-8075 1095-9203
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