FB2025_01 , released February 20, 2025
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Citation
Sano, H., Ricardo, S., Lehmann, R. (2007). Tumbling, an interactive way to move forward.  Sci. STKE 2007(412): pe63.
FlyBase ID
FBrf0216211
Publication Type
Note
Abstract
The migration of Drosophila border cells has become a powerful model with which to genetically identify guidance cues that control the directed migration of a group of interconnected cells. During oogenesis, border cells delaminate from an epithelial layer and move collectively toward the oocyte. In vivo observation has been added to the impressive experimental toolkit available to study border cell migration. These studies reveal two previously unknown migratory behaviors: one in which cells within the border cell cluster constantly change their position, and another called "tumbling," by which the entire border cell cluster rotates forward. Unexpectedly, the same receptor tyrosine kinases control these different modes of migration through separate downstream pathways. An early mode is mediated by the actin regulatory proteins ELMO and Mbc and resembles cellular polarization during individual cell migration; whereas during a later phase, communication between cells, facilitated by mitogen-activated protein kinase and phospholipase C-gamma, organizes the polarity of the entire cluster.
PubMed ID
PubMed Central ID
Related Publication(s)
Research paper

Two distinct modes of guidance signalling during collective migration of border cells.
Bianco et al., 2007, Nature 448(7151): 362--365 [FBrf0200493]

Cellular and molecular mechanisms of border cell migration analyzed using time-lapse live-cell imaging.
Prasad and Montell, 2007, Dev. Cell 12(6): 997--1005 [FBrf0202029]

Imaging the migrating border cell cluster in living Drosophila egg chambers.
Tekotte et al., 2007, Dev. Dyn. 236(10): 2818--2824 [FBrf0200453]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Sci. STKE
    Title
    Science's STKE: Signal Transduction Knowledge Environment
    Publication Year
    1999-
    ISBN/ISSN
    1525-8882
    Data From Reference