Reference Report

Reference
Citation	Thum, A.S., Leisibach, B., Gendre, N., Selcho, M., Stocker, R.F. (2011). Diversity, variability, and suboesophageal connectivity of antennal lobe neurons in D. melanogaster larvae. J. Comp. Neurol. 519(17): 3415--3432. (Export to RIS)
FlyBase ID	FBrf0216269
Publication Type	Research paper
PubMed ID	21800296
PubMed Abstract	Whereas the "vertical" elements of the insect olfactory pathway, the olfactory receptor neurons and the projection neurons, have been studied in great detail, local interneurons providing "horizontal" connections in the antennal lobe were ignored for a long time. Recent studies in adult Drosophila demonstrate diverse roles for these neurons in the integration of odor information, consistent with the identification of a large variety of anatomical and neurochemical subtypes. Here we focus on the larval olfactory circuit of Drosophila, which is much reduced in terms of cell numbers. We show that the horizontal connectivity in the larval antennal lobe differs largely from its adult counterpart. Only one of the five anatomical types of neurons we describe is restricted to the antennal lobe and therefore fits the definition of a local interneuron. Interestingly, the four remaining subtypes innervate both the antennal lobe and the suboesophageal ganglion. In the latter, they may overlap with primary gustatory terminals and with arborizations of hugin cells, which are involved in feeding control. This circuitry suggests special links between smell and taste, which may reflect the chemosensory constraints of a crawling and burrowing lifestyle. We also demonstrate that many of the neurons we describe exhibit highly variable trajectories and arborizations, especially in the suboesophageal ganglion. Together with reports from adult Drosophila, these data suggest that wiring variability may be another principle of insect brain organization, in parallel with stereotypy.
DOI	10.1002/cne.22713
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	J. Comp. Neurol.
Title	Journal of Comparative Neurology
Publication Year	1911-
ISBN/ISSN	0021-9967
Data from Reference
Alleles (28)
	Avic\GFP^{Cameleon2.1.Scer\UAS} Avic\GFP^{Gr66a.3x.IRES.2x} Avic\GFP^YFP.hug.PM Dscam^{exon17.1.Scer\UAS.T:Avic\GFP} Mmus\Cd8a^{Scer\FRT.Scer\UAS.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.S.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} n-syb^{Scer\UAS.cEa.T:Avic\GFP} Rnor\CD2^{Scer\UAS.cDBa} Scer\FLP1^hs.PG Scer\GAL4^c739 Scer\GAL4^{CG2162-NP3056} Scer\GAL4^{exba-krasavietz} Scer\GAL4^ey-OK107 Scer\GAL4^GH146 Scer\GAL4^GH298 Scer\GAL4^H24 Scer\GAL4^HB4-93 Scer\GAL4^HB8-145 Scer\GAL4^LCCH3 Scer\GAL4^lilli-189Y Scer\GAL4^nan.PK Scer\GAL4^NP0385 Scer\GAL4^NP1227 Scer\GAL4^NP6277 Scer\GAL4^orb-NP1612 Scer\GAL4^Sxl-NP2426 Scer\GAL80^mb247
Constructs (12)
	P{Gr66a-GFP.IRES.GFP.IRES.GFP} P{hsFLP} P{hug-YFP.M} P{mb247-GAL80} P{nan-GAL4.K} P{UAS(FRT.CD2.y⁺)CD8-GFP} P{UAS(-FRT)CD8-GFP} P{UAS-Cameleon.2.1} P{UAS-CD2} P{UAS-Dscam.exon17.1.GFP} P{UAS-mCD8::GFP.L} P{UAS-n-syb-GFP.E}
Genes (11)
	Avic\GFP Cha dlg1 Dscam hug Mmus\Cd8a n-syb Rnor\CD2 Scer\FLP1 Scer\GAL4 Scer\GAL80
Insertions (15)
	P{GAL4}exba^krasavietz P{GAL4}H24 P{GAL4}HB4-93 P{GAL4}HB8-145 P{GawB}CG2162^NP3056 P{GawB}ey^OK107 P{GawB}GH146 P{GawB}GH298 P{GawB}Hr39^c739 P{GawB}lilli^189Y P{GawB}LN1^NP1227 P{GawB}NP0385 P{GawB}NP6277 P{GawB}orb^NP1612 P{GawB}Sxl^NP2426
Natural transposons (1)
	P-element