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Citation
Olson, E.R., Pancratov, R., Chatterjee, S.S., Changkakoty, B., Pervaiz, Z., Dasgupta, R. (2011). Yan, an ETS-domain transcription factor, negatively modulates the Wingless pathway in the Drosophila eye.  EMBO Rep. 12(10): 1047--1054.
FlyBase ID
FBrf0216277
Publication Type
Research paper
Abstract
We report the identification of yan, an ETS-domain transcription factor belonging to the Drosophila epidermal growth factor receptor (DER) pathway, as an antagonist of the Wingless signalling pathway. We demonstrate that cells lacking yan function in the Drosophila eye show increased Wingless pathway activity, and inhibition of Wingless signalling in yan(-/-) cells rescues the yan mutant phenotype. Biochemical analysis shows that Yan physically associates with Armadillo, a crucial effector of the Wingless pathway, thereby suggesting a direct regulatory mechanism. We conclude that yan represents a new and unsuspected molecular link between the Wingless and DER pathways.
PubMed ID
PubMed Central ID
PMC3185344 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO Rep.
    Title
    EMBO Reports
    Publication Year
    2000-
    ISBN/ISSN
    1469-221X 1469-3178
    Data From Reference