Reference Report

Reference
Citation	Olson, E.R., Pancratov, R., Chatterjee, S.S., Changkakoty, B., Pervaiz, Z., Dasgupta, R. (2011). Yan, an ETS-domain transcription factor, negatively modulates the Wingless pathway in the Drosophila eye. EMBO Rep. 12(10): 1047--1054. (Export to RIS)
FlyBase ID	FBrf0216277
Publication Type	Research paper
PubMed ID	21869817
PubMed Abstract	We report the identification of yan, an ETS-domain transcription factor belonging to the Drosophila epidermal growth factor receptor (DER) pathway, as an antagonist of the Wingless signalling pathway. We demonstrate that cells lacking yan function in the Drosophila eye show increased Wingless pathway activity, and inhibition of Wingless signalling in yan(-/-) cells rescues the yan mutant phenotype. Biochemical analysis shows that Yan physically associates with Armadillo, a crucial effector of the Wingless pathway, thereby suggesting a direct regulatory mechanism. We conclude that yan represents a new and unsuspected molecular link between the Wingless and DER pathways.
DOI	10.1038/embor.2011.159
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Language of Publication	English
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Publication Type	Journal
Abbreviation	EMBO Rep.
Title	EMBO Reports
Publication Year	2000-
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Data from Reference
Alleles (18)
	aop⁴⁴³ aop⁸⁸⁴ aop^ACT.Scer\UAS aop^unspecified arm^{S10.Scer\UAS.T:Hsap\MYC} Avic\GFP^{hs.Stinger.T:nls-tra} Axn^{Scer\UAS.T:Avic\GFP} Axn^unspecified btl::Egfr^{Scer\UAS.T:λ\cI-DD} Disc\RFP^{fz3.T:nls-tra} Ecol\lacZ^wg-en11 Egfr^{DN.cUa.Scer\UAS} pan^ΔN.Scer\UAS Scer\GAL4^Act.PU Scer\GAL4^bbg-C96 Scer\GAL4^da.G32 Scer\GAL4^prd.RG1 Scer\GAL4^unspecified
Constructs (8)
	P{fz3-RFP.O} P{GAL4-da.G32} P{GAL4-prd.F} P{UAS-aop.ACT} P{UAS-arm.S10} P{UAS-Axn.GFP} P{UAS-Egfr.DN.U} P{UAS-pan.dTCFΔN}
Genes (15)
	aop arm Axn btl::Egfr dac Disc\RFP Ecol\lacZ Egfr en fz3 pan Scer\GAL4 sens T:nls-tra wg
Insertions (2)
	P{en1}wg^en11 P{GawB}bbg^C96