Reference Report

Reference
Citation	Tripura, C., Chandrika, N.P., Susmitha, V.N., Noselli, S., Shashidhara, L.S. (2011). Regulation and activity of JNK signaling in the wing disc peripodial membrane during adult morphogenesis in Drosophila. Int. J. Dev. Biol. 55(6): 583--590. (Export to RIS)
FlyBase ID	FBrf0216296
Publication Type	Research paper
PubMed ID	21948705
PubMed Abstract	Thorax closure in Drosophila is a process during adult morphogenesis in which the anterior ends of the presumptive notum of the two wing imaginal discs fuse to make a seamless thorax. Similar to dorsal closure during embryogenesis, this process is regulated by plegic and JNK signaling pathways. Despite the fact that Peripodial Membrane (PM) cells do not contribute to the formation of any adult structure, they are known to facilitate the process of thorax closure. Here we show that JNK signaling is activated only in a subset of PM cells, known as medial edge cells. While the mechanism that activates JNK signaling specifically in the medial edge cells of the PM is still not understood, the results presented here show that the pair rule gene odd skipped is required to ensure that JNK signaling is not activated anywhere else in the wing disc. Medial edge cells of the PM are elongated in shape, while the remaining PM cells are hexagonal. Down regulation of JNK signaling in the medial edge cells results in defective thorax closure in adult flies. It also causes the transformation of the morphology of medial edge cells into hexagonal shape. Conversely, activation of JNK signaling in hexagonal cells of the PM causes transformation of their morphology to elongated shape. Thus, similar to dorsal closure during embryogenesis, JNK-mediated elongation of medial edge cells is functionally correlated to the process of thorax closure.
DOI	10.1387/ijdb.103275ct
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Int. J. Dev. Biol.
Title	International Journal of Developmental Biology
Publication Year	1989-
ISBN/ISSN	0214-6282
Data from Reference
Alleles (17)
	bsk^DN.Scer\UAS bsk^Scer\UAS.cBa Ecol\lacZ^ap-rK568 Ecol\lacZ^puc-E69 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} odd^{dsRNA.Sym.Scer\UAS} puc^EP3194 Scer\GAL4^ap-md544 Scer\GAL4^Bx-MS1096 Scer\GAL4^da.G32 Scer\GAL4^en-e16E Scer\GAL4^opa Scer\GAL4^pnr-MD237 Scer\GAL4^puc-E69-unk Scer\GAL4^{Ubx-lac1-Gal4} Ubx¹ Ubx^Scer\UAS.cCa
Constructs (8)
	P{EP} P{GAL4-da.G32} P{GawB} P{UAS-bsk.B} P{UAS-bsk.DN} P{UAS-mCD8::GFP.L} P{UAS-odd.RNAi} P{UAS-Ubx.Ia.C}
Genes (8)
	arm bsk Ecol\lacZ Mmus\Cd8a odd puc Scer\GAL4 Ubx
Insertions (10)
	P{A92}puc^E69 P{en2.4-GAL4}e16E P{EP}puc^EP3194 P{GAL4}opa^GAL4 P{GawB}ap^md544 P{GawB}Bx^MS1096 P{GawB}pnr^MD237 P{GawB}puc^E69-unk P{GawB}Ubx^lac1-GAL4 P{PZ}ap^rK568
Natural transposons (1)
	P-element