Reference Report

Reference
Citation	Clark, R.I., Woodcock, K.J., Geissmann, F., Trouillet, C., Dionne, M.S. (2011). Multiple TGF-β Superfamily Signals Modulate the Adult Drosophila Immune Response. Curr. Biol. 21(19): 1672--1677. (Export to RIS)
FlyBase ID	FBrf0216429
Publication Type	Research paper
PubMed ID	21962711
PubMed Abstract	TGF-β superfamily signals play complex roles in regulation of tissue repair and inflammation in mammals [1]. Drosophila melanogaster is a well-established model for the study of innate immune function [2, 3] and wound healing [4-7]. Here, we explore the role and regulation of two TGF-β superfamily members, dawdle and decapentaplegic (dpp), in response to wounding and infection in adult Drosophila. We find that both TGF-β signals exhibit complex regulation in response to wounding and infection, each is expressed in a subset of phagocytes, and each inhibits a specific arm of the immune response. dpp is rapidly activated by wounds and represses the production of antimicrobial peptides; flies lacking dpp function display persistent, strong antimicrobial peptide expression after even a small wound. dawdle, in contrast, is activated by Gram-positive bacterial infection but repressed by Gram-negative infection or wounding; its role is to limit infection-induced melanization. Flies lacking dawdle function exhibit melanization even when uninfected. Together, these data imply a model in which the bone morphogenetic protein (BMP) dpp is an important inhibitor of inflammation following sterile injury whereas the activin-like dawdle determines the nature of the induced immune response.
DOI	10.1016/j.cub.2011.08.048
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Alleles (23)
	babo^{Q302D.Scer\UAS} daw^GD5085 daw^KK110248 daw^Scer\UAS.cSa Dif² Disc\RFP^{Hml.Δ.T:nls-tra} Disc\RFP^{hs.DsRedT4.T:nls-tra} Disc\RFP^{Scer\UAS.T:Myr-Src64B} dpp^Scer\UAS.cUa gbb^Scer\UAS.cSa Mad^GD4121 Mmus\Cd8a^{Scer\UAS.T:Disc\RFP-mCherry} Rel^E20 Rel^E38 Scer\GAL4^c564 Scer\GAL4^crq.PO Scer\GAL4^daw-NP4661 Scer\GAL4^dpp.blk1 Scer\GAL4^hs.PU Scer\GAL4^tub.PU Scer\GAL80^ts.αTub84B Tak1¹ Tl^10b.Scer\UAS
Constructs (16)
	P{crq-GAL4} P{GAL4-dpp.blk1} P{GD4121} P{GD5085} P{Hml-dsRed.Δ} P{hs-GAL4.U} P{KK110248} P{tub-GAL4.U} P{tubP-GAL80^ts} P{UAS-babo.Q302D} P{UAS-daw.S} P{UAS-dpp.U} P{UAS-mCD8.ChRFP} P{UAS-myr-mRFP} P{UAS-Tgfβ-60A.S1} P{UAS-Tl.10b}
Genes (23)
	AttA babo crq daw Def Dif Disc\RFP dpp Dpt Dro Drs gbb Hml Mad Mmus\Cd8a Mtk Rel Scer\GAL4 Scer\GAL80 Sp7 T:nls-tra Tak1 Tl
Insertions (2)
	P{GawB}c564 P{GawB}daw^NP4661
Natural transposons (1)
	P-element