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Akhouayri, I., Turc, C., Royet, J., Charroux, B. (2011). Toll-8/tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium.  PLoS Pathog. 7(10): e1002319.
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Research paper

Barrier epithelia that are persistently exposed to microbes have evolved potent immune tools to eliminate such pathogens. If mechanisms that control Drosophila systemic responses are well-characterized, the epithelial immune responses remain poorly understood. Here, we performed a genetic dissection of the cascades activated during the immune response of the Drosophila airway epithelium i.e. trachea. We present evidence that bacteria induced-antimicrobial peptide (AMP) production in the trachea is controlled by two signalling cascades. AMP gene transcription is activated by the inducible IMD pathway that acts non-cell autonomously in trachea. This IMD-dependent AMP activation is antagonized by a constitutively active signalling module involving the receptor Toll-8/Tollo, the ligand Spätzle2/DNT1 and Ect-4, the Drosophila ortholog of the human Sterile alpha and HEAT/ARMadillo motif (SARM). Our data show that, in addition to Toll-1 whose function is essential during the systemic immune response, Drosophila relies on another Toll family member to control the immune response in the respiratory epithelium.

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PMC3192845 (PMC) (EuropePMC)
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    Publication Type
    PLoS Pathog.
    PLoS Pathogens
    Publication Year
    1553-7366 1553-7374
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