Reference Report

Reference
Citation	Kwon, J.Y., Dahanukar, A., Weiss, L.A., Carlson, J.R. (2011). Molecular and cellular organization of the taste system in the Drosophila larva. J. Neurosci. 31(43): 15300--15309. (Export to RIS)
FlyBase ID	FBrf0216529
Publication Type	Research paper
PubMed ID	22031876
PubMed Abstract	We examine the molecular and cellular basis of taste perception in the Drosophila larva through a comprehensive analysis of the expression patterns of all 68 Gustatory receptors (Grs). Gr-GAL4 lines representing each Gr are examined, and 39 show expression in taste organs of the larval head, including the terminal organ (TO), the dorsal organ (DO), and the pharyngeal organs. A receptor-to-neuron map is constructed. The map defines 10 neurons of the TO and DO, and it identifies 28 receptors that map to them. Each of these neurons expresses a unique subset of Gr-GAL4 drivers, except for two neurons that express the same complement. All of these neurons express at least two drivers, and one neuron expresses 17. Many of the receptors map to only one of these cells, but some map to as many as six. Conspicuously absent from the roster of Gr-GAL4 drivers expressed in larvae are those of the sugar receptor subfamily. Coexpression analysis suggests that most larval Grs act in bitter response and that there are distinct bitter-sensing neurons. A comprehensive analysis of central projections confirms that sensory information collected from different regions (e.g., the tip of the head vs the pharynx) is processed in different regions of the suboesophageal ganglion, the primary taste center of the CNS. Together, the results provide an extensive view of the molecular and cellular organization of the larval taste system.
DOI	10.1523/JNEUROSCI.3363-11.2011
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Neurosci.
Title	Journal of Neuroscience
Publication Year	1981-
ISBN/ISSN	0270-6474 1529-2401
Data from Reference
Alleles (70)
	Disc\RFP^Orco.PK Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^Gr2a.2.2 Scer\GAL4^Gr5a.8.5 Scer\GAL4^Gr8a.0.7 Scer\GAL4^Gr9a.6.3 Scer\GAL4^Gr10a.3.7 Scer\GAL4^Gr10b.2.7 Scer\GAL4^Gr21a.9.323 Scer\GAL4^Gr22a.4.2 Scer\GAL4^Gr22b.5.8 Scer\GAL4^Gr22c.PD Scer\GAL4^Gr22d.3.1 Scer\GAL4^Gr22e.2.5 Scer\GAL4^Gr22f.2.5 Scer\GAL4^Gr23a.3.5 Scer\GAL4^Gr28a.PT Scer\GAL4^Gr28b.a.3 Scer\GAL4^Gr28b.b.4.7 Scer\GAL4^Gr28b.c.6.5 Scer\GAL4^Gr28b.d.PT Scer\GAL4^{Gr28b.e.4.245} Scer\GAL4^Gr32a.3.7.PW Scer\GAL4^Gr33a.4.7 Scer\GAL4^Gr36a.6 Scer\GAL4^Gr36b.0.9 Scer\GAL4^Gr36c.2.5 Scer\GAL4^Gr39a.a.3.4 Scer\GAL4^Gr39a.b.1 Scer\GAL4^Gr39a.c.2.4 Scer\GAL4^Gr39a.d.1.7 Scer\GAL4^Gr39b.4.4 Scer\GAL4^Gr43a.0.5 Scer\GAL4^Gr43a.5.3 Scer\GAL4^Gr47a.7.321 Scer\GAL4^Gr47b.2 Scer\GAL4^Gr57a.6 Scer\GAL4^Gr58a.1 Scer\GAL4^Gr58b.1 Scer\GAL4^Gr58c.1.1 Scer\GAL4^Gr59a.1.5 Scer\GAL4^Gr59b.PD Scer\GAL4^Gr59c.5.5 Scer\GAL4^Gr59d.4.1 Scer\GAL4^Gr59e.4.7 Scer\GAL4^Gr59f.1.8 Scer\GAL4^Gr61a.4.9 Scer\GAL4^Gr63a.0.8 Scer\GAL4^Gr64a.1.6 Scer\GAL4^Gr64b.2.4 Scer\GAL4^Gr64c.4.5 Scer\GAL4^Gr64d.6 Scer\GAL4^Gr64e.8 Scer\GAL4^Gr64f.9.7 Scer\GAL4^Gr66a.1.8 Scer\GAL4^Gr68a.PB Scer\GAL4^Gr77a.4 Scer\GAL4^Gr85a.0.7 Scer\GAL4^Gr89a.2 Scer\GAL4^Gr92a.3.9 Scer\GAL4^Gr93a.5 Scer\GAL4^Gr93b.5.3 Scer\GAL4^Gr93c.3.8 Scer\GAL4^Gr93d.2.4 Scer\GAL4^Gr94a.3.7 Scer\GAL4^Gr97a.1 Scer\GAL4^Gr98a.7.8 Scer\GAL4^Gr98b.8.9 Scer\GAL4^Gr98c.4 Scer\GAL4^Gr98d.1.6
Constructs (70)
	P{Gr2a-GAL4.2.2} P{Gr5a-GAL4.8.5} P{Gr8a-GAL4.0.7} P{Gr9a-GAL4.6.3} P{Gr10a-GAL4.3.7} P{Gr10b-GAL4.2.7} P{Gr21a-GAL4.9.323} P{Gr22a-GAL4.4.2} P{Gr22b-GAL4.5.8} P{Gr22c-GAL4.D} P{Gr22d-GAL4.3.1} P{Gr22e-GAL4.2.5} P{Gr22f-GAL4.2.5} P{Gr23a-GAL4.3.5} P{Gr28a-GAL4.T} P{Gr28b.a-GAL4.3} P{Gr28b.b-GAL4.4.7} P{Gr28b.c-GAL4.6.5} P{Gr28b.d-GAL4} P{Gr28b.e-GAL4.4.245} P{Gr32a-GAL4.3.7.PW} P{Gr33a-GAL4.4.7} P{Gr36a-GAL4.6} P{Gr36b-GAL4.0.9} P{Gr36c-GAL4.2.5} P{Gr39a.a-GAL4.3.4} P{Gr39a.b-GAL4.1} P{Gr39a.c-GAL4.2.4} P{Gr39a.d-GAL4.1.7} P{Gr39b-GAL4.4.4} P{Gr43a-GAL4.0.5} P{Gr43a-GAL4.5.3} P{Gr47a-GAL4.7.321} P{Gr47b-GAL4.2} P{Gr57a-GAL4.6} P{Gr58a-GAL4.1} P{Gr58b-GAL4.1} P{Gr58c-GAL4.1.1} P{Gr59a-GAL4.1.5} P{Gr59b-GAL4.D} P{Gr59c-GAL4.5.5} P{Gr59d-GAL4.4.1} P{Gr59e-GAL4.4.7} P{Gr59f-GAL4.1.8} P{Gr61a-GAL4.4.9} P{Gr63a-GAL4.0.8} P{Gr64a-GAL4.1.6} P{Gr64b-GAL4.2.4} P{Gr64c-GAL4.4.5} P{Gr64d-GAL4.6} P{Gr64e-GAL4.8} P{Gr64f-GAL4.9.7} P{Gr66a-GAL4.1.8} P{Gr68a-GAL4.B} P{Gr77a-GAL4.4} P{Gr85a-GAL4.0.7} P{Gr89a-GAL4.2} P{Gr92a-GAL4.3.9} P{Gr93a-GAL4.5} P{Gr93b-GAL4.5.3} P{Gr93c-GAL4.3.8} P{Gr93d-GAL4.2.4} P{Gr94a-GAL4.3.7} P{Gr97a-GAL4.1} P{Gr98a-GAL4.7.8} P{Gr98b-GAL4.8.9} P{Gr98c-GAL4.4} P{Gr98d-GAL4.1.6} P{Orco-RFP.K} P{UAS-mCD8::GFP.L}
Genes (39)
	Disc\RFP Gr2a Gr9a Gr10a Gr21a Gr22a Gr22b Gr22d Gr22e Gr23a Gr28a Gr28b Gr32a Gr33a Gr36b Gr36c Gr39a Gr39b Gr43a Gr47b Gr57a Gr58b Gr59a Gr59c Gr59d Gr59e Gr59f Gr63a Gr66a Gr68a Gr77a Gr93a Gr93b Gr93c Gr93d Gr94a Gr97a Mmus\Cd8a Scer\GAL4
Natural transposons (1)
	P-element
Transcripts (40)
	Scer\GAL4^Gr2a.2.2RA Scer\GAL4^Gr9a.6.3RA Scer\GAL4^Gr10a.3.7RA Scer\GAL4^Gr21a.9.323RA Scer\GAL4^Gr22a.4.2RA Scer\GAL4^Gr22b.5.8RA Scer\GAL4^Gr22d.3.1RA Scer\GAL4^Gr22e.2.5RA Scer\GAL4^Gr23a.3.5RA Scer\GAL4^Gr28a.PTRA Scer\GAL4^Gr28b.a.3RA Scer\GAL4^{Gr28b.e.4.245}RA Scer\GAL4^Gr32a.3.7.PWRA Scer\GAL4^Gr33a.4.7RA Scer\GAL4^Gr36b.0.9RA Scer\GAL4^Gr36c.2.5RA Scer\GAL4^Gr39a.a.3.4RA Scer\GAL4^Gr39a.b.1RA Scer\GAL4^Gr39a.d.1.7RA Scer\GAL4^Gr39b.4.4RA Scer\GAL4^Gr43a.0.5RA Scer\GAL4^Gr43a.5.3RA Scer\GAL4^Gr47b.2RA Scer\GAL4^Gr57a.6RA Scer\GAL4^Gr58b.1RA Scer\GAL4^Gr59a.1.5RA Scer\GAL4^Gr59c.5.5RA Scer\GAL4^Gr59d.4.1RA Scer\GAL4^Gr59e.4.7RA Scer\GAL4^Gr59f.1.8RA Scer\GAL4^Gr63a.0.8RA Scer\GAL4^Gr66a.1.8RA Scer\GAL4^Gr68a.PBRA Scer\GAL4^Gr77a.4RA Scer\GAL4^Gr93a.5RA Scer\GAL4^Gr93b.5.3RA Scer\GAL4^Gr93c.3.8RA Scer\GAL4^Gr93d.2.4RA Scer\GAL4^Gr94a.3.7RA Scer\GAL4^Gr97a.1RA