Reference Report

Reference
Citation	Vasiliauskas, D., Mazzoni, E.O., Sprecher, S.G., Brodetskiy, K., Johnston, R.J., Lidder, P., Vogt, N., Celik, A., Desplan, C. (2011). Feedback from rhodopsin controls rhodopsin exclusion in Drosophila photoreceptors. Nature 479(7371): 108--112. (Export to RIS)
FlyBase ID	FBrf0216554
Publication Type	Research paper
PubMed ID	21983964
PubMed Abstract	Sensory systems with high discriminatory power use neurons that express only one of several alternative sensory receptor proteins. This exclusive receptor gene expression restricts the sensitivity spectrum of neurons and is coordinated with the choice of their synaptic targets. However, little is known about how it is maintained throughout the life of a neuron. Here we show that the green-light sensing receptor rhodopsin 6 (Rh6) acts to exclude an alternative blue-sensitive rhodopsin 5 (Rh5) from a subset of Drosophila R8 photoreceptor neurons. Loss of Rh6 leads to a gradual expansion of Rh5 expression into all R8 photoreceptors of the ageing adult retina. The Rh6 feedback signal results in repression of the rh5 promoter and can be mimicked by other Drosophila rhodopsins; it is partly dependent on activation of rhodopsin by light, and relies on G(αq) activity, but not on the subsequent steps of the phototransduction cascade. Our observations reveal a thus far unappreciated spectral plasticity of R8 photoreceptors, and identify rhodopsin feedback as an exclusion mechanism.
DOI	10.1038/nature10451
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Aberrations (1)
	Df(3R)Exel6174
Alleles (24)
	Avic\GFP^{Ecol\lexAop.cVa} Ecol\lacZ^{int1.melt.T:SV40\nls2} Ecol\lacZ^Rh6.-470 Ecol\lacZ^wts-P1X Ecol\lacZ^wts-P509-19 Ecol\lexA^Rh5 Gαq¹ ninaE^Scer.UAS.cVa norpA³⁶ Rh3¹ Rh3^Scer.UAS.cVa Rh4¹ Rh4^Scer.UAS.cVa Rh5² Rh5^Scer.UAS.cVa Rh6¹ Rh6^+t2.6 Rh6^fs Rh6^KK110924 Rh6^Scer.UAS.cVa Scer\GAL4^Rh6.PD sev¹⁴ trp² trpl³⁰²
Constructs (12)
	P{KK110924} P{lexAop-GFP.V} P{melt-lacZ.int1.nls} P{Rh5-lexA} P{Rh6^+t2.6} P{Rh6-GAL4.D} P{Rh6-lacZ.-470} P{UAS-ninaE.V} P{UAS-Rh3.V} P{UAS-Rh4.V} P{UAS-Rh5.V} P{UAS-Rh6.V}
Genes (18)
	Avic\GFP CG14870 Ecol\lacZ Ecol\lexA Gαq melt ninaE norpA Rh3 Rh4 Rh5 Rh6 Scer\GAL4 sev Trissin trp trpl wts
Insertions (2)
	P{lacW}wts^P1X P{lacW}wts^P509-19
Natural transposons (1)
	P-element