Reference Report

Reference
Citation	Poon, C.L., Lin, J.I., Zhang, X., Harvey, K.F. (2011). The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway. Dev. Cell 21(5): 896--906. (Export to RIS)
FlyBase ID	FBrf0216620
Publication Type	Research paper
PubMed ID	22075148
PubMed Abstract	The Salvador-Warts-Hippo (SWH) pathway is a complex signaling network that controls both developmental and regenerative tissue growth. Using a genetic screen in Drosophila melanogaster, we identified the sterile 20-like kinase, Tao-1, as an SWH pathway member. Tao-1 controls various biological phenomena, including microtubule dynamics, animal behavior, and brain development. Here we describe a role for Tao-1 as a regulator of epithelial tissue growth that modulates activity of the core SWH pathway kinase cassette. Tao-1 functions together with Hippo to activate Warts-mediated repression of Yorkie. Tao-1's ability to control SWH pathway activity is evolutionarily conserved because human TAO1 can suppress activity of the Yorkie ortholog, YAP. Human TAO1 controls SWH pathway activity by phosphorylating, and activating, the Hippo ortholog, MST2. Given that SWH pathway activity is subverted in many human cancers, our findings identify human TAO kinases as potential tumor suppressor genes.
DOI	10.1016/j.devcel.2011.09.012
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Alleles (32)
	Avic\GFP^{EGFP.ban.αTub84B} Avic\GFP^Scer\UAS.cUa d^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} Ecol\lacZ^ex-697 Ecol\lacZ^Scer\UAS.cUa ex^GD12782 ft^KK101190 ft^{ΔECD.Scer\UAS} Gal^GD936 hpo^{dsRNA.Scer\UAS} hpo^GMR.PW kibra^KK111409 Mer^NIG.14228R Pten^{dsRNA.Exel.Scer\UAS} sav² sav^GMR.PT Scer\GAL4^32B Scer\GAL4^71B Scer\GAL4^en-e16E Scer\GAL4^GMR.PF Scer\GAL4^hh.PU Scer\GAL4^rn-GAL4-5 Tao⁵⁰ Tao^{D168A.Scer\UAS.P\T.T:Zzzz\FLAG} Tao^EP1455 Tao^GD8262 Tao^KK108458 Tao^{Scer\UAS.P\T.T:Zzzz\FLAG} wts^GMR.PT wts^P2 wts^{Scer\UAS.T:Hsap\MYC} yki^{S168A.Scer\UAS.T:Avic\GFP-YFP}
Constructs (23)
	P{GAL4-ninaE.GMR} P{GD936} P{GD8262} P{GD12782} P{GMR-hpo.W} P{GMR-sav.T} P{GMR-wts.T} P{hh-GAL4.U} P{KK101190} P{KK108458} P{KK111409} P{NIG.14228R} P{Tub-EGFP.ban} P{UAS-d.V5} P{UAS-ft.ΔECD} P{UAS-GFP.U} P{UAS-lacZ.U} P{UASp-Tao.D168A.FLAG} P{UASp-Tao.FLAG} P{UAS-Pten.dsRNA.Exel} P{UAS-RNAi-hpo.P} P{UAS-wts.MYC} P{UAS-yki.S168A.YFP}
Genes (20)
	Avic\GFP ban ci d Ecol\lacZ ex ft Gal hpo kibra mats Mer Pten sav Scer\GAL4 sd Tao Wbp2 wts yki
Insertions (6)
	P{en2.4-GAL4}e16E P{EP}Tao^EP1455 P{GawB}32B P{GawB}71B P{GawB}rn^GAL4-5 P{lacW}ex⁶⁹⁷
Natural transposons (1)
	P-element