Reference Report

Reference
Citation	Zhang, Y., Wheatley, R., Fulkerson, E., Tapp, A., Estes, P.A. (2011). Mastermind Mutations Generate a Unique Constellation of Midline Cells within the Drosophila CNS. PLoS ONE 6(10): e26197. (Export to RIS)
FlyBase ID	FBrf0216654
Publication Type	Research paper
PubMed ID	22046261
PubMed Abstract	The Notch pathway functions repeatedly during the development of the central nervous system in metazoan organisms to control cell fate and regulate cell proliferation and asymmetric cell divisions. Within the Drosophila midline cell lineage, which bisects the two symmetrical halves of the central nervous system, Notch is required for initial cell specification and subsequent differentiation of many midline lineages.Here, we provide the first description of the role of the Notch co-factor, mastermind, in the central nervous system midline of Drosophila. Overall, zygotic mastermind mutations cause an increase in midline cell number and decrease in midline cell diversity. Compared to mutations in other components of the Notch signaling pathway, such as Notch itself and Delta, zygotic mutations in mastermind cause the production of a unique constellation of midline cell types. The major difference is that midline glia form normally in zygotic mastermind mutants, but not in Notch and Delta mutants. Moreover, during late embryogenesis, extra anterior midline glia survive in zygotic mastermind mutants compared to wild type embryos.This is an example of a mutation in a signaling pathway cofactor producing a distinct central nervous system phenotype compared to mutations in major components of the pathway.
DOI	10.1371/journal.pone.0026197
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS ONE
Title	PLoS ONE
Publication Year	2006-
ISBN/ISSN	1932-6203
Data from Reference
Aberrations (3)
	Df(2R)50C-38 Df(2R)BSC18 Df(2R)BSC383
Alleles (10)
	Avic\GFP^{S65T.Scer\UAS} Avic\GFP^{W.wrapper.T:nls-tra} mam⁸ mam^Scer\UAS.cGa mam^ΔC N^55e11 N^{Intra1768.Scer\UAS.T:Zzzz\FLAG} Scer\GAL4^sim.P3.7 spi^s.Scer\UAS Su(H)^{Scer\UAS.T:Hsap\MYC,T:Hsim\VP16}
Constructs (7)
	P{GAL4-sim.3.7} P{UAS-GFP.S65T} P{UAS-mam.G} P{UAS-N.Intra.1768.T:FLAG} P{UAS-spi.s} P{UAS-Su(H).VP16} P{wrapper-GFP.W}
Genes (14)
	Avic\GFP CG13565 en mam N odd ple run Scer\GAL4 sim spi Su(H) Tbh wrapper