Reference Report

Reference
Citation	Mathew, S.J., Rembold, M., Leptin, M. (2011). Role for traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes. Mol. Cell. Biol. 31(24): 4978--4993. (Export to RIS)
FlyBase ID	FBrf0216703
Publication Type	Research paper
PubMed ID	21986496
PubMed Abstract	Apical constriction of epithelial cells is a widely used morphogenetic mechanism. In the Drosophila embryo, the apical constrictions that internalize the mesoderm are controlled by the transcription factor Twist and require intact adherens junctions and a contractile acto-myosin network. We find that adherens junctions in constricting mesodermal cells undergo extensive remodeling. A Twist target gene encoding a member of the tumor necrosis factor (TNF) receptor-associated factor (TRAF) family, Traf4, is involved in this process. While TRAFs are best known for their functions in inflammatory responses, Traf4 appears to have a different role, and its mechanism of action is poorly understood. We show that Traf4 is required for efficient apical constriction during ventral furrow formation and for proper localization of Armadillo to the apical position in constricting cells. Traf4 and Armadillo interact with each other physically and functionally. Traf4 acts in a TNF receptor- and Jun N-terminal protein kinase (JNK)-independent manner to fine-tune the assembly of adherens junctions in the invaginating mesodermal cells.
DOI	10.1128/MCB.05542-11
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Cell. Biol.
Title	Molecular and Cellular Biology
Publication Year	1981-
ISBN/ISSN	0270-7306
Data from Reference
Aberrations (2)
	Df(2L)TE35D-11 Df(3R)CC1.2
Alleles (27)
	aos::shg^{i.Scer\UAS.T:Hsap\MYC} arm¹ arm² arm⁴ arm^{+mOa.T:Avic\GFP} arm^Scer\UAS.cWa bif^R47 bsk^Scer\UAS.cBa bsk^unspecified cta^R10 egr^Scer\UAS.cMa hep^Scer\UAS.cBa Mpk2¹ msn^DN.Scer\UAS msn^Scer\UAS.cSa p38b^a.Scer\UAS puc^Scer\UAS.cMa Scer\GAL4^en.PU Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} Scer\GAL4^twi.PG Traf4³ Traf4^ex1 Traf4^L2 Traf4^Scer\UAS.cMa Traf4^{Scer\UAS.T:Ivir\HA1} Traf6^ex1 twi^ey53
Constructs (15)
	P{arm-GFP.P} P{en-GAL4.U} P{GAL4-twi.G} P{matα4-GAL-VP16} P{UAS-arm.W} P{UAS-bsk.B} P{UAS-eiger.M} P{UAS-hep.B} P{UAS-msn.DN} P{UAS-msn.S} P{UAS-p38b.a} P{UAS-puc.M} P{UAS-shg.CADⁱ} P{UAS-Traf1.HA} P{UAS-Traf4.M}
Genes (30)
	aos::shg aPKC arm baz bif bsk cno crb cta dlg1 egr eve fog hep Mpk2 msn Nrt p38b par-6 puc RhoGEF2 Scer\GAL4 scrib sdt shg sna T48 Traf4 Traf6 twi
Natural transposons (1)
	P-element