Reference Report

Reference
Citation	Rosenbaum, E.E., Brehm, K.S., Vasiljevic, E., Liu, C.H., Hardie, R.C., Colley, N.J. (2011). XPORT-Dependent Transport of TRP and Rhodopsin. Neuron 72(4): 602--615. (Export to RIS)
FlyBase ID	FBrf0216705
Publication Type	Research paper
PubMed ID	22099462
PubMed Abstract	TRP channels have emerged as key biological sensors in vision, taste, olfaction, hearing, and touch. Despite their importance, virtually nothing is known about the folding and transport of TRP channels during biosynthesis. Here, we identify XPORT (exit protein of rhodopsin and TRP) as a critical chaperone for TRP and its G protein-coupled receptor (GPCR), rhodopsin (Rh1). XPORT is a resident ER and secretory pathway protein that interacts with TRP and Rh1, as well as with Hsp27 and Hsp90. XPORT promotes the targeting of TRP to the membrane in Drosophila S2 cells, a finding that provides a critical first step toward solving a longstanding problem in the successful heterologous expression of TRP. Mutations in xport result in defective transport of TRP and Rh1, leading to retinal degeneration. Our results identify XPORT as a molecular chaperone and provide a mechanistic link between TRP channels and their GPCRs during biosynthesis and transport.
DOI	10.1016/j.neuron.2011.09.016
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
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Parent Publication
Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (2)
	Df(3R)BSC636 Df(3R)ED6027
Alleles (15)
	Arr1¹ Arr2³ chp² Cnx99A¹ eya¹ Gαq¹ ninaA³ ninaE¹⁷ ninaE³¹⁸ ninaE^{hs.T:Btau\1D4} norpA³⁶ trp⁹ trpl³⁰² Xport¹ Xport^ninaE.PR
Constructs (2)
	P{hs-Rh1} P{ninaE-Xport.R}
Genes (18)
	Arr1 Arr2 chp Cnx99A eya Gαq Hsp27 Hsp83 ninaA ninaE norpA Rh3 Rh4 Rh5 Syn trp trpl Xport
Natural transposons (1)
	P-element