|Citation||Hadad, M., Bresler-Musikant, T., Neuman-Silberberg, F.S. (2011). Drosophila spoonbill encodes a dual-specificity A-kinase anchor protein essential for oogenesis. Mech. Dev. 128(7-10): 471--482. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||spoonbill is a Drosophila female-sterile mutation, which interferes with normal egg patterning during oogenesis. Previous analyzes linked the mutation to a number of seemingly unrelated pathways, including GRK/EGFR and DPP, two major pathways essential for Drosophila and vertebrate development. Further work suggested that spoonbill may also function in actin polymerization and border-cell migration. Here we describe the molecular cloning of the spoonbill gene and characterize new mutant alleles, further demonstrating that spoonbill's function is essential during oogenesis. We found spoonbill to be allelic to CG3249 (also known as yu), which encodes the only known dual-specificity A-kinase anchor protein in Drosophila. Our data indicate that similar to mammalian AKAPs, Spoonbill protein contains a number of potential kinase and phosphatase binding motifs, and is targeted, in the ovary, to mitochondria and Golgi. Finally, we address some of spoonbill's mutant phenotypes from the perspective of the published data on the AKAP protein family.|
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|Language of Publication||English|
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|Title||Mechanisms of Development|
|Data from Reference|
|Natural transposons (1)|