Reference Report

Reference
Citation	Hadad, M., Bresler-Musikant, T., Neuman-Silberberg, F.S. (2011). Drosophila spoonbill encodes a dual-specificity A-kinase anchor protein essential for oogenesis. Mech. Dev. 128(7-10): 471--482. (Export to RIS)
FlyBase ID	FBrf0216765
Publication Type	Research paper
PubMed ID	21983075
PubMed Abstract	spoonbill is a Drosophila female-sterile mutation, which interferes with normal egg patterning during oogenesis. Previous analyzes linked the mutation to a number of seemingly unrelated pathways, including GRK/EGFR and DPP, two major pathways essential for Drosophila and vertebrate development. Further work suggested that spoonbill may also function in actin polymerization and border-cell migration. Here we describe the molecular cloning of the spoonbill gene and characterize new mutant alleles, further demonstrating that spoonbill's function is essential during oogenesis. We found spoonbill to be allelic to CG3249 (also known as yu), which encodes the only known dual-specificity A-kinase anchor protein in Drosophila. Our data indicate that similar to mammalian AKAPs, Spoonbill protein contains a number of potential kinase and phosphatase binding motifs, and is targeted, in the ovary, to mitochondria and Golgi. Finally, we address some of spoonbill's mutant phenotypes from the perspective of the published data on the AKAP protein family.
DOI	10.1016/j.mod.2011.09.002
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (11)
	Df(1)BA2-8 Df(1)bi-D2 Df(1)C149 Df(1)Exel6234 Df(1)Exel6235 Df(1)Exel6290 Df(1)HC244 Df(1)JC70 Df(1)ovo4 Df(1)ovo41 Df(1)RC40
Alleles (8)
	Avic\GFP^{EYFP.sqh.T:Hsap\mito} spoon¹ spoon^+t8 spoon^EP1400 spoon^exc36-18 spoon^exc36-32 spoon^exc57 spoon^exc58
Constructs (3)
	P{spoon.8} P{sqh-EYFP-Mito} P{unk}
Genes (7)
	Avic\GFP CG4165 CG16756 Glg1 KdelR NAAT1 spoon
Insertions (2)
	P{EP}spoon^EP1400 P{unk}spoon^EP1400-P2
Natural transposons (1)
	P-element