Reference Report

Reference
Citation	Wisotsky, Z., Medina, A., Freeman, E., Dahanukar, A. (2011). Evolutionary differences in food preference rely on Gr64e, a receptor for glycerol. Nat. Neurosci. 14(12): 1534--1541. (Export to RIS)
FlyBase ID	FBrf0216771
Publication Type	Research paper
PubMed ID	22057190
PubMed Abstract	Very little is known about how stimuli that are typically not rich in sugars, such as beer, trigger attractive gustatory responses in Drosophila. We identified a member of the gustatory receptor family, Gr64e, as a receptor that is required for feeding preference for beer and other sources that have fermenting yeast. We found that Gr64e is required for neuronal and behavioral responses to glycerol, an abundant component of growing yeast and fermentation products. Ectopic expression of Gr64e in an olfactory neuron conferred responsiveness to glycerol. We also found that Drosophila species that are predicted to carry pseudogenes of Gr64e had reduced glycerol sensitivity. Our results provide insight into the molecular mechanisms of feeding acceptance of yeast products and raise the possibility that Gr64e contributes to specific evolutionary variations in appetitive selectivity across Drosophila species.
DOI	10.1038/nn.2944
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Nat. Neurosci.
Title	Nature Neuroscience
Publication Year	1998-
ISBN/ISSN	1097-6256
Data from Reference
Alleles (10)
	Gr5a^ΔEP5 Gr64e^MB03533 Gr64e^Scer\UAS.cWa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Orco¹ Scer\GAL4^E409 Scer\GAL4^Gr5a.8.5 Scer\GAL4^Gr21a.9.323 Scer\GAL4^Gr63a.PF Scer\GAL4^Gr64e.8
Constructs (6)
	P{Gr5a-GAL4.8.5} P{Gr21a-GAL4.9.323} P{Gr63a-GAL4.F} P{Gr64e-GAL4.8} P{UAS-Gr64e.W} P{UAS-mCD8::GFP.L}
Genes (17)
	Dana\Gr64e Dere\Gr64e Dgri\Gr64e Dmoj\Gr64e Dper\Gr64e Dpse\Gr64e Dsec\Gr64e Dsim\Gr64e Dvir\Gr64e Dwil\Gr64e Dyak\Gr64e Gr5a Gr64d Gr64e Mmus\Cd8a Orco Scer\GAL4
Insertions (2)
	Mi{ET1}Gr64e^MB03533 P{GawB}E409
Natural transposons (1)
	P-element
Transcripts (1)
	Scer\GAL4^Gr64e.8RA