Reference Report

Reference
Citation	Itoh, T.Q., Tanimura, T., Matsumoto, A. (2011). Membrane-bound transporter controls the circadian transcription of clock genes in Drosophila. Genes Cells 16(12): 1159--1167. (Export to RIS)
FlyBase ID	FBrf0216813
Publication Type	Research paper
PubMed ID	22077638
PubMed Abstract	Little is known about molecular mechanisms that control the Drosophila circadian clock beyond the transcriptional-translational feedback regulation of clock genes as an intracellular process. In this study, Early gene at 23 (E23) was identified as a novel clock gene that encodes the membrane-bound ABC transporter that is induced by the molting hormone ecdysone. E23 expresses in pacemaker neurons in fly head, and its knockdown flies lengthened circadian period with an increased expression of the clock gene vrille. E23 and vrille responded to both ecdysone and clock signals, whereas E23 protein specifically suppressed the ecdysone response and is necessary for rhythmicity. Thus, E23 forms its own feedback loop in the ecdysone response to control circadian oscillation through ecdysone-mediated vrille expression. The ecdysone signaling pathway with E23 is essential not only in developmental stage but also for the circadian behavior in adult fly.
DOI	10.1111/j.1365-2443.2011.01559.x
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Cells
Title	Genes to cells : devoted to molecular & cellular mechanisms
Publication Year	1996-
ISBN/ISSN	1356-9597
Data from Reference
Alleles (8)
	E23^NIG.15410R E23^Scer\UAS.cIa EcR^NIG.1765R Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} phm^KK103215 Scer\GAL4^E23G4.5 Scer\GAL4^P2.4.Pdf usp^NIG.4380R
Constructs (8)
	P{E23G4.5-GAL4} P{KK103215} P{NIG.1765R} P{NIG.4380R} P{NIG.15410R} P{Pdf-GAL4.P2.4} P{UAS-E23.I} P{UAS-mCD8::GFP.L}
Genes (12)
	Clk cyc E23 EcR Mmus\Cd8a Pdp1 per phm Scer\GAL4 tim usp vri
Natural transposons (1)
	P-element