Reference Report

Reference
Citation	Buechling, T., Chaudhary, V., Spirohn, K., Weiss, M., Boutros, M. (2011). p24 proteins are required for secretion of Wnt ligands. EMBO Rep. 12(12): 1265--1272. (Export to RIS)
FlyBase ID	FBrf0216831
Publication Type	Research paper
PubMed ID	22094269
PubMed Abstract	During development and disease, the exocytosis of signalling molecules, such as Wnt ligands, is essential to orchestrate cellular programs in multicellular organisms. However, it remains a largely unresolved question whether signalling molecules follow specialized transport routes through the exocytic pathway. Here we identify several Drosophila p24 proteins that are required for Wnt signalling. We demonstrate that one of these p24 proteins, namely Opossum, shuttles in the early secretory pathway, and that the Drosophila Wnt proteins are retained in the absence of p24 proteins. Our results indicate that Wnt secretion relies on a specialized anterograde secretion route with p24 proteins functioning as conserved cargo receptors.
DOI	10.1038/embor.2011.212
Related Publication(s)
Note	Wnts need a p(assport)24 to leave the ER. Palmer et al., 2011, EMBO Rep. 12(12): 1207--1208 [FBrf0217809]
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	EMBO Rep.
Title	EMBO Reports
Publication Year	2000-
ISBN/ISSN
Data from Reference
Alleles (12)
	Avic\GFP^Scer\UAS.cUa Avic\GFP^{Scer\UAS.T:Uuuu\KDEL} CHOp24^GD3225 opm^9.3 opm^GD3366 opm^{Scer\UAS.T:Ivir\HA1} p24-1^GD3321 Rel^KK109851 Scer\GAL4^en.PU Scer\GAL4^wg.PM wls^KK101700 wntD^KO1
Constructs (10)
	P{en-GAL4.U} P{GAL4-wg.M} P{GD3225} P{GD3321} P{GD3366} P{KK101700} P{KK109851} P{UAS-GFP.KDEL} P{UAS-GFP.U} P{UAS-opm.HA}
Genes (23)
	arm arr Avic\GFP CHOp24 CkIα dl dsh fz hh lgs opm os p24-1 pan pygo Rel Scer\GAL4 sens sgg T:Ivir\HA1 wg wls wntD
Natural transposons (1)
	P-element