Reference Report

Reference
Citation	Li, Y., Hoxha, V., Lama, C., Dinh, B.H., Vo, C.N., Dauwalder, B. (2011). The hector G-Protein Coupled Receptor Is Required in a Subset of fruitless Neurons for Male Courtship Behavior. PLoS ONE 6(11): e28269. (Export to RIS)
FlyBase ID	FBrf0216834
Publication Type	Research paper
PubMed ID	22140564
PubMed Abstract	Male courtship behavior in Drosophila melanogaster is controlled by two main regulators, fruitless (fru) and doublesex (dsx). Their sex-specific expression in brain neurons has been characterized in detail, but little is known about the downstream targets of the sex-specific FRU and DSX proteins and how they specify the function of these neurons. While sexual dimorphism in the number and connections of fru and dsx expressing neurons has been observed, a majority of the neurons that express the two regulators are present in both sexes. This poses the question which molecules define the sex-specific function of these neurons. Signaling molecules are likely to play a significant role. We have identified a predicted G-protein coupled receptor (GPCR), CG4395, that is required for male courtship behavior. The courtship defect in the mutants can be rescued by expression of the wildtype protein in fru neurons of adult males. The GPCR is expressed in a subset of fru-positive antennal glomeruli that have previously been shown to be essential for male courtship. Expression of 4395-RNAi in GH146 projection neurons lowers courtship. This suggests that signaling through the CG4395 GPCR in this subset of fru neurons is critical for male courtship behavior.
DOI	10.1371/journal.pone.0028269
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	PLoS ONE
Title	PLoS ONE
Publication Year	2006-
ISBN/ISSN	1932-6203
Data from Reference
Alleles (20)
	Avic\GFP^{2xhrGFP.Ecol\lexA.T:SV40\nls2} Avic\GFP^{Scer\UAS.T:SV40\nls2} desat1^1573-1 Disc\RFP^{Ecol\lexAop.T:Uuuu\Myr5} Disc\RFP^{tdTomato.Ncra\QUAS.T:Uuuu\MyrPalm2,T:Ivir\HA1} Ecol\lacZ^{Scer\UAS.T:SV40\nls2} Ecol\lexA^{fru.P1.T:Hsim\VP16} fru⁴ hec^f04274 hec^f06077 hec^GD724 hec^Scer\UAS.cLa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Ncra\QF^GH146.PP Scer\GAL4^fru.P1.D Scer\GAL4^GH146 Scer\GAL4^hec.PL Scer\GAL4^Mef2.247 Scer\GAL80^ts.αTub84B tra^Scer\UAS.cFa
Constructs (13)
	P{GD724} P{hec-GAL4.L} P{lexA-2xhrGFP.nls} P{lexAop-mCherry.myr} P{Mef2-GAL4.247} P{QUAS-mtdTomato-3xHA} P{tubP-GAL80^ts} P{UAS-GFP.nls} P{UAS-hec.L} P{UAS-lacZ.NZ} P{UAS-mCD8::GFP.L} P{UAS-tra.F} PBac{GH146-QF.P}
Genes (12)
	Avic\GFP desat1 Disc\RFP Ecol\lacZ Ecol\lexA fru hec Mmus\Cd8a Ncra\QF Scer\GAL4 Scer\GAL80 tra
Insertions (13)
	P{GawB}GH146 P{GD724}v7223 P{lexA-2xhrGFP.nls}2a P{QUAS-mtdTomato-3xHA}24A P{tubP-GAL80^ts}20 P{UAS-GFP.nls}14 P{UAS-lacZ.NZ}20b P{UAS-lacZ.NZ}J312 P{UAS-mCD8::GFP.L}LL5 P{UAS-tra.F}20J7 PBac{GH146-QF.P}53 PBac{WH}hec^f04274 PBac{WH}hec^f06077
Natural transposons (1)
	P-element