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Citation
Sinenko, S.A., Shim, J., Banerjee, U. (2011). Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila.  EMBO Rep. 13(1): 83--89.
FlyBase ID
FBrf0217071
Publication Type
Research paper
Abstract
Oxidative stress induced by high levels of reactive oxygen species (ROS) is associated with the development of different pathological conditions, including cancers and autoimmune diseases. We analysed whether oxidatively challenged tissue can have systemic effects on the development of cellular immune responses using Drosophila as a model system. Indeed, the haematopoietic niche that normally maintains blood progenitors can sense oxidative stress and regulate the cellular immune response. Pathogen infection induces ROS in the niche cells, resulting in the secretion of an epidermal growth factor-like cytokine signal that leads to the differentiation of specialized cells involved in innate immune responses.
PubMed ID
PubMed Central ID
PMC3246251 (PMC) (EuropePMC)
Related Publication(s)
Supplementary material
Note
Immune cell transdifferentiation: a complex crosstalk between circulating immune cells and the haematopoietic niche.
Meister and Ferrandon, 2012, EMBO Rep. 13(1): 3--4 [FBrf0218128]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO Rep.
    Title
    EMBO Reports
    Publication Year
    2000-
    ISBN/ISSN
    1469-221X 1469-3178
    Data From Reference