Reference Report

Reference
Citation	Sinenko, S.A., Shim, J., Banerjee, U. (2011). Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila. EMBO Rep. 13(1): 83--89. (Export to RIS)
FlyBase ID	FBrf0217071
Publication Type	Research paper
PubMed ID	22134547
PubMed Abstract	Oxidative stress induced by high levels of reactive oxygen species (ROS) is associated with the development of different pathological conditions, including cancers and autoimmune diseases. We analysed whether oxidatively challenged tissue can have systemic effects on the development of cellular immune responses using Drosophila as a model system. Indeed, the haematopoietic niche that normally maintains blood progenitors can sense oxidative stress and regulate the cellular immune response. Pathogen infection induces ROS in the niche cells, resulting in the secretion of an epidermal growth factor-like cytokine signal that leads to the differentiation of specialized cells involved in innate immune responses.
DOI	10.1038/embor.2011.223
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Supplementary material	Supplementary information. [FBrf0219127]
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Language of Publication	English
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Publication Type	Journal
Abbreviation	EMBO Rep.
Title	EMBO Reports
Publication Year	2000-
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Data from Reference
Aberrations (1)
	Df(2R)Egfr18
Alleles (28)
	Akt1^GD1361 Akt1^KK100495 Avic\GFP^Scer\UAS.cUa bsk^DN.Scer\UAS btl::Egfr^{Scer\UAS.T:λ\cI-DD} Ecol\lacZ^Thor-k13517 Egfr^{DN.Scer\UAS.cBa} Egfr^tsla foxo^Scer\UAS.cPa ND75^GD6309 rho^{T:Avic\GFP-YFP} S¹ Scer\GAL4⁵⁰¹⁵ Scer\GAL4^A58 Scer\GAL4^Antp-10 Scer\GAL4^ap-md544 Scer\GAL4^btl.PS Scer\GAL4^c127 Scer\GAL4^dome-PG14 Scer\GAL4^Dot.PK Scer\GAL4^HCH.Hand Scer\GAL4^HHLT Scer\GAL4^Hml.Δ Scer\GAL4^Lsp2.PH Sod2^Scer\UAS.cMa spi^NIG.10334R spi^s.Scer\UAS vn^Scer\UAS.cSa
Constructs (19)
	P{Dot-GAL4.K} P{GAL4-btl.S} P{GD1361} P{GD6309} P{HCH-GAL4} P{HHLT-Gal4} P{Hml-GAL4.Δ} P{KK100495} P{Lsp2-GAL4.H} P{NIG.10334R} P{UAS-bsk.DN} P{UAS-Egfr.DN.B} P{UAS-Egfr.λtop} P{UAS-foxo.P} P{UAS-GFP.U} P{UAS-Sod2.M} P{UAS-spi.s} P{UAS-vn.S} PBac{rho-GFP}
Genes (30)
	Akt1 Antp Avic\GFP bsk btl::Egfr CoVa dome Dot Ecol\lacZ Egfr egr foxo Hml Marf ND75 os Pdsw PHGPx puc rho rl rpr S Scer\GAL4 Sod2 spi Thor upd3 vn W
Insertions (7)
	P{GAL4}A58 P{GawB}5015 P{GawB}Antp-10 P{GawB}ap^md544 P{GawB}c127 P{GawB}dome^PG14 P{lacW}Thor^k13517
Natural transposons (1)
	Tni\piggyBac