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Citation
Hadar, N., Yaron, S., Oren, Z., Elly, O., Itamar, W., Johnathan, G., Tama, D., Offer, G. (2012). A screen identifying genes responsive to Dpp and Wg signaling in the Drosophila developing wing.  Gene 494(1): 65--72.
FlyBase ID
FBrf0217293
Publication Type
Research paper
Abstract
Morphogens control developmental decisions by regulating the expression of different sets of target genes in specific regions. The products of these genes drive the region specific developmental program and lead to the formation of different adult structures. Therefore, identification of the morphogens downstream target effectors is an essential step in deciphering the mechanisms underlying organ development. In the Drosophila developing wing, signaling by the morphogens Decapentaplegic (Dpp) and Wingless (Wg) plays global roles in controlling differentiation, growth, and survival. However, only a handful of their downstream target genes have been identified. Here, we describe a screening method designed to quickly search through large collections of P-Gal4 enhancer-traps for candidate genes that are transcriptionally regulated by Dpp or Wg signaling. Using this screening method, we screened a small collection of lethal P-Gal4 insertion lines that are expressed in the wing disc. We identified 10 novel putative Dpp and/or Wg target genes in the developing wing. Further study of the roles of the genes recognized in this screen should shed light on how morphogens control various processes in organ development.
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Gene
    Title
    Gene
    Publication Year
    1976-
    ISBN/ISSN
    0378-1119
    Data From Reference
    Alleles (63)
    Genes (46)
    Insertions (47)
    Transgenic Constructs (1)