Open Close
Kim, J.Y., Jang, W., Lee, H.W., Park, E., Kim, C. (2012). Neurodegeneration of Drosophila drop-dead mutants is associated with hypoxia in the brain.  Genes Brain Behav. 11(2): 177--184.
FlyBase ID
Publication Type
Research paper
The Drosophila drop-dead (drd) mutant undergoes massive brain degeneration, resulting in sudden death. drd encodes a multi-pass membrane protein possessing nose resistant to fluoxetine (NRF) and putative acyltransferase domains. However, the etiology of brain degeneration that occurs in drd mutant flies is still poorly understood. Herein, we show that drd neurodegeneration may be because of an oxygen deficit in the brain. We found that DRD protein is selectively expressed in cells secreting cuticular and eggshell layers. These layers exhibit blue fluorescence upon UV excitation, which is reduced in drd flies. The drd tracheal air sacs lacking blue fluorescence collapse, which likely contributes to hypoxia. Consistently, genes induced in hypoxia are up-regulated in drd flies. Feeding of anti-reactive oxygen species agents partially rescue the drd from sudden death. We propose that drd flies can provide a non-invasive animal model for hypoxia-induced cell death.
PubMed ID
PubMed Central ID
Associated Information
Associated Files
Other Information
Secondary IDs
    Language of Publication
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Genes Brain Behav.
    Genes, Brain, and Behavior
    Publication Year
    1601-1848 1601-183X
    Data From Reference
    Genes (7)