Reference Report

Reference
Citation	Plavicki, J., Mader, S., Pueschel, E., Peebles, P., Boekhoff-Falk, G. (2012). Homeobox gene distal-less is required for neuronal differentiation and neurite outgrowth in the Drosophila olfactory system. Proc. Natl. Acad. Sci. U.S.A. 109(5): 1578--1583. (Export to RIS)
FlyBase ID	FBrf0217395
Publication Type	Research paper
PubMed ID	22307614
PubMed Abstract	Vertebrate Dlx genes have been implicated in the differentiation of multiple neuronal subtypes, including cortical GABAergic interneurons, and mutations in Dlx genes have been linked to clinical conditions such as epilepsy and autism. Here we show that the single Drosophila Dlx homolog, distal-less, is required both to specify chemosensory neurons and to regulate the morphologies of their axons and dendrites. We establish that distal-less is necessary for development of the mushroom body, a brain region that processes olfactory information. These are important examples of distal-less function in an invertebrate nervous system and demonstrate that the Drosophila larval olfactory system is a powerful model in which to understand distal-less functions during neurogenesis.
DOI	10.1073/pnas.1016741109
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Aberrations (1)
	Df(2R)Dll-MP
Alleles (16)
	amos¹ ato¹ ct^C145 Dcr-2^Scer\UAS.cDa Dll¹ Dll³ Dll⁷ Dll¹⁷ Dll^JF02499 Ecol\lacZ^Dll-01092 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} para^sbl-1 Scer\GAL4^Dll-md23 Scer\GAL4^elav-C155 Scer\GAL4^ey-OK107 Scer\GAL4^{Orco.2.642.T:Hsim\VP22}
Constructs (4)
	P{Orco-GAL4.W} P{TRiP.JF02499} P{UAS-Dcr-2.D} P{UAS-mCD8::GFP.L}
Genes (14)
	amos ato ct dac Dcr-2 Dll Ecol\lacZ elav Fas2 Mmus\Cd8a para pros Scer\GAL4 sens
Insertions (4)
	P{GawB}Dll^md23 P{GawB}elav^C155 P{GawB}ey^OK107 P{PZ}Dll⁰¹⁰⁹²