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Citation
Mackay, T.F., Richards, S., Stone, E.A., Barbadilla, A., Ayroles, J.F., Zhu, D., Casillas, S., Han, Y., Magwire, M.M., Cridland, J.M., Richardson, M.F., Anholt, R.R., Barrón, M., Bess, C., Blankenburg, K.P., Carbone, M.A., Castellano, D., Chaboub, L., Duncan, L., Harris, Z., Javaid, M., Jayaseelan, J.C., Jhangiani, S.N., Jordan, K.W., Lara, F., Lawrence, F., Lee, S.L., Librado, P., Linheiro, R.S., Lyman, R.F., Mackey, A.J., Munidasa, M., Muzny, D.M., Nazareth, L., Newsham, I., Perales, L., Pu, L.L., Qu, C., Ràmia, M., Reid, J.G., Rollmann, S.M., Rozas, J., Saada, N., Turlapati, L., Worley, K.C., Wu, Y.Q., Yamamoto, A., Zhu, Y., Bergman, C.M., Thornton, K.R., Mittelman, D., Gibbs, R.A. (2012). The Drosophila melanogaster Genetic Reference Panel.  Nature 482(7384): 173--178.
FlyBase ID
FBrf0217434
Publication Type
Research paper
Abstract

A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics.

PubMed ID
PubMed Central ID
PMC3683990 (PMC) (EuropePMC)
Related Publication(s)
Note

Population genetics: A population genomic resource for Drosophila melanogaster.
Anonymous, 2012, Nat. Rev. Genet. 13(3): 149 [FBrf0217528]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nature
    Title
    Nature
    Publication Year
    1869-
    ISBN/ISSN
    0028-0836
    Data From Reference