Reference Report

Reference
Citation	Ito, S., Fujiyama-Nakamura, S., Kimura, S., Lim, J., Kamoshida, Y., Shiozaki-Sato, Y., Sawatsubashi, S., Suzuki, E., Tanabe, M., Ueda, T., Murata, T., Kato, H., Ohtake, F., Fujiki, R., Miki, T., Kouzmenko, A., Takeyama, K., Kato, S. (2012). Epigenetic Silencing of Core Histone Genes by HERS in Drosophila. Mol. Cell 45(4): 494--504. (Export to RIS)
FlyBase ID	FBrf0217607
Publication Type	Research paper
PubMed ID	22365829
PubMed Abstract	Cell cycle-dependent expression of canonical histone proteins enables newly synthesized DNA to be integrated into chromatin in replicating cells. However, the molecular basis of cell cycle-dependency in the switching of histone gene regulation remains to be uncovered. Here, we report the identification and biochemical characterization of a molecular switcher, HERS (histone gene-specific epigenetic repressor in late S phase), for nucleosomal core histone gene inactivation in Drosophila. HERS protein is phosphorylated by a cyclin-dependent kinase (Cdk) at the end of S-phase. Phosphorylated HERS binds to histone gene regulatory regions and anchors HP1 and Su(var)3-9 to induce chromatin inactivation through histone H3 lysine 9 methylation. These findings illustrate a salient molecular switch linking epigenetic gene silencing to cell cycle-dependent histone production.
DOI	10.1016/j.molcel.2011.12.029
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mol. Cell
Title	Molecular Cell
Publication Year	1997-
ISBN/ISSN	1097-2765 1097-4164
Data from Reference
Aberrations (1)
	In(1)w^m4h
Alleles (14)
	amn^{dsRNA.Scer\UAS} Avic\GFP^8xARE E(var)7¹ Hers^{dsRNA.Scer\UAS} Hers^GS7466 Hers^MB07095 Hers^{Scer\UAS.T:Zzzz\FLAG} Hsap\AR^{AF-1.Scer\UAS} nej³ Rpd3⁰⁴⁵⁵⁶ Scer\GAL4^GMR.PU Su(var)2-10¹ Su(var)3-9¹ Su(var)205⁴
Constructs (7)
	P{GMR-GAL4.U} P{GSV2} P{hsp70-ARE-white-ARE-GFP} P{UAS-amn.ds} P{UAS-Hers.ds} P{UAS-Hers.FLAG} P{UAS-Hsap\AR.AF-1}
Genes (22)
	amn Avic\GFP cdc2 CycA E(var)7 Hers His1 His2A His2B His3 His3.3A His3.3B His4 Hsap\AR nej Rpd3 RpII215 Scer\GAL4 Su(var)2-10 Su(var)3-9 Su(var)205 T:Zzzz\FLAG
Insertions (1)
	P{GSV2}Hers^GS7466
Natural transposons (1)
	P-element