Reference Report

Reference
Citation	Hergarden, A.C., Tayler, T.D., Anderson, D.J. (2012). Allatostatin-A neurons inhibit feeding behavior in adult Drosophila. Proc. Natl. Acad. Sci. U.S.A. 109(10): 3967--3972. (Export to RIS)
FlyBase ID	FBrf0217661
Publication Type	Research paper
PubMed ID	22345563
PubMed Abstract	How the brain translates changes in internal metabolic state or perceived food quality into alterations in feeding behavior remains poorly understood. Studies in Drosophila larvae have yielded information about neuropeptides and circuits that promote feeding, but a peptidergic neuron subset whose activation inhibits feeding in adult flies, without promoting metabolic changes that mimic the state of satiety, has not been identified. Using genetically based manipulations of neuronal activity, we show that activation of neurons (or neuroendocrine cells) expressing the neuropeptide allatostatin A (AstA) inhibits or limits several starvation-induced changes in feeding behavior in adult Drosophila, including increased food intake and enhanced behavioral responsiveness to sugar. Importantly, these effects on feeding behavior are observed in the absence of any measurable effects on metabolism or energy reserves, suggesting that AstA neuron activation is likely a consequence, not a cause, of metabolic changes that induce the state of satiety. These data suggest that activation of AstA-expressing neurons promotes food aversion and/or exerts an inhibitory influence on the motivation to feed and implicate these neurons and their associated circuitry in the mechanisms that translate the state of satiety into alterations in feeding behavior.
DOI	10.1073/pnas.1200778109
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Alleles (8)
	Bhal\NaChBac^Scer\UAS.cNa Hsap\KCNJ2^{Scer\UAS.T:Avic\GFP-EGFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^Ast.2.1 Scer\GAL4^Gr5a.8.5 Scer\GAL4^npf.1 Scer\GAL80^ts.αTub84B TrpA1^Scer\UAS.cKa
Constructs (8)
	P{AstA-GAL4.2.1} P{Gr5a-GAL4.8.5} P{npf-GAL4.1} P{tubP-GAL80^ts} P{UAS-Hsap\KCNJ2.EGFP} P{UAS-mCD8::GFP.L} P{UAS-NaChBac} P{UAS-TrpA1.K}
Genes (10)
	Ast Bhal\NaChBac brp Crz Hsap\KCNJ2 Mmus\Cd8a npf Scer\GAL4 Scer\GAL80 TrpA1
Natural transposons (1)
	P-element
Transcripts (1)
	Scer\GAL4^Ast.2.1RA