Open Close
Reference
Citation
Hergarden, A.C., Tayler, T.D., Anderson, D.J. (2012). Allatostatin-A neurons inhibit feeding behavior in adult Drosophila.  Proc. Natl. Acad. Sci. U.S.A. 109(10): 3967--3972.
FlyBase ID
FBrf0217661
Publication Type
Research paper
Abstract

How the brain translates changes in internal metabolic state or perceived food quality into alterations in feeding behavior remains poorly understood. Studies in Drosophila larvae have yielded information about neuropeptides and circuits that promote feeding, but a peptidergic neuron subset whose activation inhibits feeding in adult flies, without promoting metabolic changes that mimic the state of satiety, has not been identified. Using genetically based manipulations of neuronal activity, we show that activation of neurons (or neuroendocrine cells) expressing the neuropeptide allatostatin A (AstA) inhibits or limits several starvation-induced changes in feeding behavior in adult Drosophila, including increased food intake and enhanced behavioral responsiveness to sugar. Importantly, these effects on feeding behavior are observed in the absence of any measurable effects on metabolism or energy reserves, suggesting that AstA neuron activation is likely a consequence, not a cause, of metabolic changes that induce the state of satiety. These data suggest that activation of AstA-expressing neurons promotes food aversion and/or exerts an inhibitory influence on the motivation to feed and implicate these neurons and their associated circuitry in the mechanisms that translate the state of satiety into alterations in feeding behavior.

PubMed ID
PubMed Central ID
PMC3309792 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Neuropeptide-GAL4 constructs and insertions.
Asahina and Anderson, 2013.9.23, Neuropeptide-GAL4 constructs and insertions. [FBrf0222772]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Alleles (8)
    Genes (10)
    Sequence Features (2)
    Natural transposons (1)
    Experimental Tools (1)
    Transgenic Constructs (8)
    Transcripts (1)