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Citation
Igboin, C.O., Griffen, A.L., Leys, E.J. (2012). The Drosophila melanogaster host model.  J. Oral Microbiol. 4(): .
FlyBase ID
FBrf0217663
Publication Type
Review
Abstract

The deleterious and sometimes fatal outcomes of bacterial infectious diseases are the net result of the interactions between the pathogen and the host, and the genetically tractable fruit fly, Drosophila melanogaster, has emerged as a valuable tool for modeling the pathogen-host interactions of a wide variety of bacteria. These studies have revealed that there is a remarkable conservation of bacterial pathogenesis and host defence mechanisms between higher host organisms and Drosophila. This review presents an in-depth discussion of the Drosophila immune response, the Drosophila killing model, and the use of the model to examine bacterial-host interactions. The recent introduction of the Drosophila model into the oral microbiology field is discussed, specifically the use of the model to examine Porphyromonas gingivalis-host interactions, and finally the potential uses of this powerful model system to further elucidate oral bacterial-host interactions are addressed.

PubMed ID
PubMed Central ID
PMC3285217 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Oral Microbiol.
    Title
    Journal of oral microbiology
    ISBN/ISSN
    2000-2297
    Data From Reference