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Citation
Couturier, L., Vodovar, N., Schweisguth, F. (2012). Endocytosis by Numb breaks Notch symmetry at cytokinesis.  Nat. Cell Biol. 14(2): 131--139.
FlyBase ID
FBrf0217937
Publication Type
Research paper
Abstract

Cell-fate diversity can be generated by the unequal segregation of the Notch regulator Numb at mitosis in both vertebrates and invertebrates. Whereas the mechanisms underlying unequal inheritance of Numb are understood, how Numb antagonizes Notch has remained unsolved. Live imaging of Notch in sensory organ precursor cells revealed that nuclear Notch is detected at cytokinesis in the daughter cell that does not inherit Numb. Numb and Sanpodo act together to regulate Notch trafficking and establish directional Notch signalling at cytokinesis. We propose that unequal segregation of Numb results in increased endocytosis in one daughter cell, hence asymmetry of Notch at the cytokinetic furrow, directional signalling and binary fate choice.

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Note

Notch signaling: numb makes the difference.
Giebel and Wodarz, 2012, Curr. Biol. 22(4): R133--R135 [FBrf0217603]

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Cell Biol.
    Title
    Nature Cell Biology
    Publication Year
    1999-
    ISBN/ISSN
    1465-7392 1476-4679
    Data From Reference