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| Citation | Seong, K.M., Kim, C.S., Lee, B.S., Nam, S.Y., Yang, K.H., Kim, J.Y., Park, J.J., Min, K.J., Jin, Y.W. (2012). Low-dose Radiation Induces Drosophila Innate Immunity through Toll Pathway Activation. J. Radiat. Res. 53(2): 242--249. (Export to RIS) | ||
| FlyBase ID | FBrf0218044 | ||
| Publication Type | Research paper | ||
| PubMed ID | 22374403 | ||
| PubMed Abstract | Numerous studies report that exposing certain organisms to low-dose radiation induces beneficial effects on lifespan, tumorigenesis, and immunity. By analyzing survival after bacterial infection and antimicrobial peptide gene expression in irradiated flies, we demonstrate that low-dose irradiation of Drosophila enhances innate immunity. Low-dose irradiation of flies significantly increased resistance against gram-positive and gram-negative bacterial infections, as well as expression of several antimicrobial peptide genes. Additionally, low-dose irradiation also resulted in a specific increase in expression of key proteins of the Toll signaling pathway and phosphorylated forms of p38 and JNK. These results indicate that innate immunity is activated after low-dose irradiation through Toll signaling pathway in Drosophila. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | J. Radiat. Res. | ||
| Title | Journal of Radiation Research | ||
| Publication Year | 1960- | ||
| ISBN/ISSN | 0449-3060 | ||
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Data from Reference
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| Genes (14)
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