|Citation||Seong, K.M., Kim, C.S., Lee, B.S., Nam, S.Y., Yang, K.H., Kim, J.Y., Park, J.J., Min, K.J., Jin, Y.W. (2012). Low-dose Radiation Induces Drosophila Innate Immunity through Toll Pathway Activation. J. Radiat. Res. 53(2): 242--249. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||Numerous studies report that exposing certain organisms to low-dose radiation induces beneficial effects on lifespan, tumorigenesis, and immunity. By analyzing survival after bacterial infection and antimicrobial peptide gene expression in irradiated flies, we demonstrate that low-dose irradiation of Drosophila enhances innate immunity. Low-dose irradiation of flies significantly increased resistance against gram-positive and gram-negative bacterial infections, as well as expression of several antimicrobial peptide genes. Additionally, low-dose irradiation also resulted in a specific increase in expression of key proteins of the Toll signaling pathway and phosphorylated forms of p38 and JNK. These results indicate that innate immunity is activated after low-dose irradiation through Toll signaling pathway in Drosophila.|
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|Language of Publication||English|
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|Also Published As|
|Abbreviation||J. Radiat. Res.|
|Title||Journal of Radiation Research|
|Data from Reference|