Reference Report

Reference
Citation	Hong, W., Mosca, T.J., Luo, L. (2012). Teneurins instruct synaptic partner matching in an olfactory map. Nature 484(7393): 201--207. (Export to RIS)
FlyBase ID	FBrf0218059
Publication Type	Research paper
PubMed ID	22425994
PubMed Abstract	Neurons are interconnected with extraordinary precision to assemble a functional nervous system. Compared to axon guidance, far less is understood about how individual pre- and postsynaptic partners are matched. To ensure the proper relay of olfactory information in the fruitfly Drosophila, axons of ∼50 classes of olfactory receptor neurons (ORNs) form one-to-one connections with dendrites of ∼50 classes of projection neurons (PNs). Here, using genetic screens, we identified two evolutionarily conserved, epidermal growth factor (EGF)-repeat containing transmembrane Teneurin proteins, Ten-m and Ten-a, as synaptic-partner-matching molecules between PN dendrites and ORN axons. Ten-m and Ten-a are highly expressed in select PN-ORN matching pairs. Teneurin loss- and gain-of-function cause specific mismatching of select ORNs and PNs. Finally, Teneurins promote homophilic interactions in vitro, and Ten-m co-expression in non-partner PNs and ORNs promotes their ectopic connections in vivo. We propose that Teneurins instruct matching specificity between synaptic partners through homophilic attraction.
DOI	10.1038/nature10926
Related Publication(s)
Supplementary material	Online methods. [FBrf0219840]
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Aberrations (1)
	Df(1)Ten-a
Alleles (24)
	Mmus\Cd8a^{Ncra\QUAS.T:Avic\GFP} Mmus\Cd8a^{Or23a.Avic\GFP.T:Hsap\MYC} Mmus\Cd8a^{Scer\FRT.Scer\UAS.cHa.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.cHa.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Ncra\QF^Mz19.PH Rnor\CD2^Or47b.PM Rnor\CD2^Or88a.PB Scer\FLP1^ey.PN Scer\FLP1^GH146.PP Scer\GAL4^AM29 Scer\GAL4^elav-C155 Scer\GAL4^GH146 Scer\GAL4^Mz19 Scer\GAL4^peb-GAL4 Scer\GAL4^Ten-m-NP6658 Scer\GAL80^{Scer\FRT.αTub84B} Scer\GAL80^αTub84B.PB Syt1^{Scer\UAS.T:Ivir\HA1} Ten-a^GD8834 Ten-a^GE1914 Ten-m^GD3620 Ten-m^GS9267 Ten-m^{Ncra\QUAS.cHa}
Constructs (14)
	M{QUAS-Ten-m.H} P{ey-FLP.N} P{GD3620} P{GD8834} P{Or23a-Mmus\Cd8a.GFP} P{Or47b-CD2.M} P{Or88a-CD2.B} P{QUAS-mCD8-GFP.P} P{tubP(FRT.stop)GAL80} P{UAS(FRT.stop)mCD8-GFP.H} P{UAS-HA-syt} P{UAS-mCD8::GFP.L} PBac{GH146-FLPo.P} PBac{Mz19-QF.H}
Genes (10)
	CadN Mmus\Cd8a Ncra\QF Rnor\CD2 Scer\FLP1 Scer\GAL4 Scer\GAL80 Syt1 Ten-a Ten-m
Insertions (8)
	P{EP}Ten-a^GE1914 P{GAL4}AM29 P{GAL4}peb^GAL4 P{GawB}elav^C155 P{GawB}GH146 P{GawB}Mz19 P{GawB}Ten-m^NP6658 P{GSV6}Ten-m^GS9267
Transcripts (2)
	Ncra\QF^Mz19.PHRA Scer\GAL4^Ten-m-NP6658RA