|Citation||Colombani, J., Andersen, D.S., Léopold, P. (2012). Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing. Science 336(6081): 582--585. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||Little is known about how organ growth is monitored and coordinated with the developmental timing in complex organisms. In insects, impairment of larval tissue growth delays growth and morphogenesis, revealing a coupling mechanism. We carried out a genetic screen in Drosophila to identify molecules expressed by growing tissues participating in this coupling and identified dilp8 as a gene whose silencing rescues the developmental delay induced by abnormally growing tissues. dilp8 is highly induced in conditions where growth impairment produces a developmental delay. dilp8 encodes a peptide for which expression and secretion are sufficient to delay metamorphosis without affecting tissue integrity. We propose that Dilp8 peptide is a secreted signal that coordinates the growth status of tissues with developmental timing.|
|Note||How growth abnormalities delay "puberty" in Drosophila.
Hariharan, 2012, Sci. Signal. 5(229): pe27 [FBrf0218616]
Drosophila growth and development: Keeping things in proportion.
Andersen et al., 2012, Cell Cycle 11(16): 2971--2972 [FBrf0219268]
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|Language of Publication||English|
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|Natural transposons (1)|