Reference Report

Reference
Citation	Colombani, J., Andersen, D.S., Léopold, P. (2012). Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing. Science 336(6081): 582--585. (Export to RIS)
FlyBase ID	FBrf0218236
Publication Type	Research paper
PubMed ID	22556251
PubMed Abstract	Little is known about how organ growth is monitored and coordinated with the developmental timing in complex organisms. In insects, impairment of larval tissue growth delays growth and morphogenesis, revealing a coupling mechanism. We carried out a genetic screen in Drosophila to identify molecules expressed by growing tissues participating in this coupling and identified dilp8 as a gene whose silencing rescues the developmental delay induced by abnormally growing tissues. dilp8 is highly induced in conditions where growth impairment produces a developmental delay. dilp8 encodes a peptide for which expression and secretion are sufficient to delay metamorphosis without affecting tissue integrity. We propose that Dilp8 peptide is a secreted signal that coordinates the growth status of tissues with developmental timing.
DOI	10.1126/science.1216689
Related Publication(s)
Note	How growth abnormalities delay "puberty" in Drosophila. Hariharan, 2012, Sci. Signal. 5(229): pe27 [FBrf0218616] Drosophila growth and development: Keeping things in proportion. Andersen et al., 2012, Cell Cycle 11(16): 2971--2972 [FBrf0219268]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Science
Title	Science
Publication Year	1895-
ISBN/ISSN	0036-8075
Data from Reference
Aberrations (1)
	Df(3L)Ilp8^Ex
Alleles (9)
	Avic\GFP^Scer\UAS.cUa Ilp8^KK112161 Ilp8^Scer\UAS.cCa Ilp8^Δ.Scer\UAS puc^Scer\UAS.cMa RpL7^GD11462 Scer\GAL4^ptc-559.1 Scer\GAL4^rn-GAL4-5 Syx7^GD2767
Constructs (7)
	P{GD2767} P{GD11462} P{KK112161} P{UAS-GFP.U} P{UAS-Ilp8.C} P{UAS-Ilp8.Δ} P{UAS-puc.M}
Genes (14)
	Avic\GFP CG7730 CG43250 dib dlg1 Eip75B Ilp8 phm Ptth puc RpL7 Scer\GAL4 Syx7 wg
Insertions (2)
	P{GawB}ptc^559.1 P{GawB}rn^GAL4-5
Natural transposons (1)
	P-element