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Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.M., Hoffmann, J.A. (2012). Pillars Article: The Dorsoventral Regulatory Gene Cassette spatzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults. Cell. 1996. 86: 973-983.  J. Immunol. 188(11): 5210--5220.
FlyBase ID
FBrf0218343
Publication Type
Research paper
Abstract

The cytokine-induced activation cascade of NF-kappaB in mammals and the activation of the morphogen dorsal in Drosophila embryos show striking structural and functional similarities (Toll/IL-1, Cactus/I-kappaB, and dorsal/NF-kappaB). Here we demonstrate that these parallels extend to the immune response of Drosophila. In particular, the intracellular components of the dorsoventral signaling pathway (except for dorsal) and the extracellular Toll ligand, spƤtzle regulatory gene cassette, control expression of the antifungal peptide gene drosomycin in adults. We also show that mutations in the Toll signaling pathway dramatically reduce survival after fungal infection. Antibacterial genes are induced either by a distinct pathway involving the immune deficiency gene (imd) or by combined activation of both imd and dorsoventral pathways.

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How Discovery of Toll-Mediated Innate Immunity in Drosophila Impacted Our Understanding of TLR Signaling (and Vice Versa).
Vogel, 2012, J. Immunol. 188(11): 5207--5209 [FBrf0218383]

Also Published As
Research paper
Lemaitre et al., 1996, Cell 86(6): 973--983
The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. [FBrf0090665]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Immunol.
    Title
    Journal of Immunology
    Publication Year
    1950-
    ISBN/ISSN
    0022-1767
    Data From Reference
    Genes (15)