Reference Report

Reference
Citation	Gummalla, M., Maeda, R.K., Castro Alvarez, J.J., Gyurkovics, H., Singari, S., Edwards, K.A., Karch, F., Bender, W. (2012). abd-A Regulation by the iab-8 Noncoding RNA. PLoS Genet. 8(5): e1002720. (Export to RIS)
FlyBase ID	FBrf0218472
Publication Type	Research paper
PubMed ID	22654672
PubMed Abstract	The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior dominance rule must be qualified in the case of abdominal-A (abd-A) repression by Abdominal-B (Abd-B). Animals lacking Abd-B show ectopic expression of abd-A in the epidermis of the eighth abdominal segment, but not in the central nervous system. Repression in these neuronal cells is accomplished by a 92 kb noncoding RNA. This "iab-8 RNA" produces a micro RNA to repress abd-A, but also has a second, redundant repression mechanism that acts only "in cis." Transcriptional interference with the abd-A promoter is the most likely mechanism.
DOI	10.1371/journal.pgen.1002720
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS Genet.
Title	PLoS Genetics
Publication Year	2005-
ISBN/ISSN	1553-7404 1553-7390
Data from Reference
Aberrations (19)
	Ab(?;3)iab3^86A Ab(?;3)iab3⁵⁰²² Ab(?;3)iab3^B1 Ab(?;3)iab-4¹⁸⁶ Ab(?;3)iab4²³³⁰ Df(3R)abd-A^iab4,5-DB Df(3R)C4 Df(3R)P9 Df(3R)ΔmiRNA Df(Ab;3)iab4.5³²⁴⁵ Dp(3;2)D109 In(3LR)iab3³³ In(3LR)iab6¹¹ In(3LR)iab7^MX2 In(3R)iab7^SGA T(2;3;4)iab4³⁰² T(2;3)abd-A^MX1 Tp(3;2)iab5⁸⁴³ Tp(3;3)iab3²⁷⁷
Alleles (8)
	Abd-B^D18 Abd-B^Fab-3,5 Abd-B^Fab7-1 Abd-B^iab-6,7.IH Abd-B^iab8-D14 Abd-B^iab8-D16 iab-8⁰⁵⁶⁴⁹ iab-8^Scer\UAS.cGa
Constructs (2)
	Mi{Hto-WP} P{UAS-iab-8.G}
Genes (5)
	abd-A Abd-B iab-8 mir-iab-8 Ubx
Insertions (2)
	Mi{Hto-WP}LNP P{PZ}Abd-B⁰⁵⁶⁴⁹
Natural transposons (2)
	Dhyd\Minos P-element