Reference Report

Reference
Citation	Newton, F.G., Zur Lage, P.I., Karak, S., Moore, D.J., Göpfert, M.C., Jarman, A.P. (2012). Forkhead Transcription Factor Fd3F Cooperates with Rfx to Regulate a Gene Expression Program for Mechanosensory Cilia Specialization. Dev. Cell 22(6): 1221--1233. (Export to RIS)
FlyBase ID	FBrf0218629
Publication Type	Research paper
PubMed ID	22698283
PubMed Abstract	Cilia have evolved hugely diverse structures and functions to participate in a wide variety of developmental and physiological processes. Ciliary specialization requires differences in gene expression, but few transcription factors are known to regulate this, and their molecular function is unclear. Here, we show that the Drosophila Forkhead box (Fox) gene, fd3F, is required for specialization of the mechanosensory cilium of chordotonal (Ch) neurons. fd3F regulates genes for Ch-specific axonemal dyneins and TRPV ion channels, which are required for sensory transduction, and retrograde transport genes, which are required to differentiate their distinct motile and sensory ciliary zones. fd3F is reminiscent of vertebrate Foxj1, a motile cilia regulator, but fd3F regulates motility genes as part of a broader sensory regulation program. Fd3F cooperates with the pan-ciliary transcription factor, Rfx, to regulate its targets directly. This illuminates pathways involved in ciliary specialization and the molecular mechanism of transcription factors that regulate them.
DOI	10.1016/j.devcel.2012.05.010
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Aberrations (1)
	Df(1)ED6716
Alleles (18)
	Avic\GFP^{Dhc93AB.820.F1m} Avic\GFP^{Dhc93AB.820.F2m} Avic\GFP^{Dhc93AB.820.Xm} Avic\GFP^Dhc93AB.820 Avic\GFP^{hs.Stinger.T:nls-tra} Avic\GFP^iav.597.F1m Avic\GFP^iav.597.Xm Avic\GFP^iav.597 Avic\GFP^nan.557.F1m Avic\GFP^nan.557.Xm Avic\GFP^nan.557 fd3F¹ fd3F^EP1198 fd3F^Scer\UAS.cNa nompB^{T:Avic\GFP-EGFP} rempA^{T:Avic\GFP-YFP.Venus} Rfx⁴⁹ Scer\GAL4^sca.PU
Constructs (14)
	P{Dhc93AB-GFP.820.F1m} P{Dhc93AB-GFP.820.F2m} P{Dhc93AB-GFP.820.Xm} P{Dhc93AB-GFP.820} P{EGFP-nompB} P{iav-GFP.597.F1m} P{iav-GFP.597.Xm} P{iav-GFP.597} P{nan-GFP.557.F1m} P{nan-GFP.557.Xm} P{nan-GFP.557} P{rempA⁺-YFP} P{sca-GAL4.U} P{UAS-fd3F.N}
Genes (27)
	Avic\GFP btv CG3769 CG6971 CG8800 CG11253 CG13930 CG14905 CG15161 CG31320 Dhc16F Dhc62B Dhc93AB fd3F futsch iav nan nompB nompC Oseg6 rempA Rfx robls54B Scer\GAL4 T:nls-tra Tektin-A tilB
Natural transposons (1)
	P-element
Transcripts (3)
	Avic\GFP^Dhc93AB.820RA Avic\GFP^iav.597RA Avic\GFP^nan.557RA