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Gistelinck, M., Lambert, J.C., Callaerts, P., Dermaut, B., Dourlen, P. (2012). Drosophila models of tauopathies: what have we learned?  Int. J. Alzheimers Dis. 2012(): 970980.
FlyBase ID
FBrf0218643
Publication Type
Review
Abstract
Aggregates of the microtubule-associated protein Tau are neuropathological hallmark lesions in Alzheimer's disease (AD) and related primary tauopathies. In addition, Tau is genetically implicated in a number of human neurodegenerative disorders including frontotemporal dementia (FTD) and Parkinson's disease (PD). The exact mechanism by which Tau exerts its neurotoxicity is incompletely understood. Here, we give an overview of how studies using the genetic model organism Drosophila over the past decade have contributed to the molecular understanding of Tau neurotoxicity. We compare the different available readouts for Tau neurotoxicity in flies and review the molecular pathways in which Tau has been implicated. Finally, we emphasize that the integration of genome-wide approaches in human or mice with high-throughput genetic validation in Drosophila is a fruitful approach.
PubMed ID
PubMed Central ID
PMC3373119 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Int. J. Alzheimers Dis.
    Title
    International journal of Alzheimer's disease
    ISBN/ISSN
    2090-0252 2090-8024
    Data From Reference