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Citation
Kounatidis, I., Ligoxygakis, P. (2012). Drosophila as a model system to unravel the layers of innate immunity to infection.  Open Biol. 2(5): 120075.
FlyBase ID
FBrf0218704
Publication Type
Review
Abstract

Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about innate immunity and host-pathogen interactions. Here, we review current research in the field, encompassing all layers of defence from the role of the microbiota to systemic immune activation, and attempt to speculate on future directions and open questions.

PubMed ID
PubMed Central ID
PMC3376734 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Open Biol.
    Title
    Open biology
    ISBN/ISSN
    2046-2441
    Data From Reference