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Citation
Chen, H., Xu, Z., Mei, C., Yu, D., Small, S. (2012). A system of repressor gradients spatially organizes the boundaries of Bicoid-dependent target genes.  Cell 149(3): 618--629.
FlyBase ID
FBrf0218713
Publication Type
Research paper
Abstract

The homeodomain (HD) protein Bicoid (Bcd) is thought to function as a gradient morphogen that positions boundaries of target genes via threshold-dependent activation mechanisms. Here, we analyze 66 Bcd-dependent regulatory elements and show that their boundaries are positioned primarily by repressive gradients that antagonize Bcd-mediated activation. A major repressor is the pair-rule protein Runt (Run), which is expressed in an opposing gradient and is necessary and sufficient for limiting Bcd-dependent activation. Evidence is presented that Run functions with the maternal repressor Capicua and the gap protein Kruppel as the principal components of a repression system that correctly orders boundaries throughout the anterior half of the embryo. These results put conceptual limits on the Bcd morphogen hypothesis and demonstrate how the Bcd gradient functions within the gene network that patterns the embryo.

Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC3535481 (PMC) (EuropePMC)
Related Publication(s)
Note

Does the bicoid gradient matter?
Roth and Lynch, 2012, Cell 149(3): 511--512 [FBrf0218155]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Alleles (49)
    Genes (14)
    Sequence Features (37)
    Natural transposons (1)
    Experimental Tools (1)
    Transgenic Constructs (43)