Reference Report

Reference
Citation	Maehara, K., Murata, T., Aoyama, N., Matsuno, K., Sawamura, K. (2012). Genetic dissection of Nucleoporin 160 (Nup160), a gene involved in multiple phenotypes of reproductive isolation in Drosophila. Genes & Genet. Systems 87(2): 99--106. (Export to RIS)
FlyBase ID	FBrf0218968
Publication Type	Research paper
PubMed ID	22820383
PubMed Abstract	Previous reports have suggested that the Nucleoporin 160 (Nup160) gene of Drosophila simulans (Nup160(sim)) causes the hybrid inviability, female sterility, and morphological anomalies that are observed in crosses with D. melanogaster. Here we have confirmed this observation by transposon excision from the P{EP}Nup160(EP372) insertion mutation of D. melanogaster. Null mutations of the Nup160 gene resulted in the three phenotypes caused by Nup160(sim), but revertants of the gene did not. Interestingly, several mutations produced by excision partially complemented hybrid inviability, female sterility, or morphological anomalies. In the future, these mutations will be useful to further our understanding of the developmental mechanisms of reproductive isolation. Based on our analyses with the Nup160(sim) introgression line, the lethal phase of hybrid inviability was determined to be during the early pupal stage. Our analysis also suggested that homozygous Nup160(sim) in D. melanogaster leads to slow development. Thus, Nup160(sim) is involved in multiple aspects of reproductive isolation between these two species.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Genes & Genet. Systems
Title	Genes & Genetic Systems
Publication Year	1996-
ISBN/ISSN	1341-7568
Data from Reference
Aberrations (7)
	Df(2L)BSC242 Df(2L)EP372M190 Df(2L)EP372M201 Df(2L)EP372M203 Df(2L)EP372M219 Dsim\Int(2L)D Dsim\Int(2L)S
Alleles (28)
	Dsim\Lhr^unspecified Nup160^e00704 Nup160^EP372 Nup160^EP372M18 Nup160^EP372M25 Nup160^EP372M26 Nup160^EP372M39 Nup160^EP372M54 Nup160^EP372M55 Nup160^EP372M64 Nup160^EP372M69 Nup160^EP372M75 Nup160^EP372M85 Nup160^EP372M94 Nup160^EP372M121 Nup160^EP372M123 Nup160^EP372M133 Nup160^EP372M142 Nup160^EP372M161 Nup160^EP372M180 Nup160^EP372M185 Nup160^EP372M206 Nup160^EP372M215 Nup160^EP372M227 Nup160^EP372M230 Nup160^EP372M241 Nup160^SH2055 RfC38^k13807
Constructs (1)
	P{?EP}
Genes (7)
	CG6230 CG14921 Csl4 Dsim\Lhr Dsim\Nup160 Nup160 RfC38
Insertions (27)
	P{?EP}Nup160^EP372M18 P{?EP}Nup160^EP372M25 P{?EP}Nup160^EP372M26 P{?EP}Nup160^EP372M39 P{?EP}Nup160^EP372M54 P{?EP}Nup160^EP372M55 P{?EP}Nup160^EP372M64 P{?EP}Nup160^EP372M69 P{?EP}Nup160^EP372M75 P{?EP}Nup160^EP372M85 P{?EP}Nup160^EP372M94 P{?EP}Nup160^EP372M121 P{?EP}Nup160^EP372M123 P{?EP}Nup160^EP372M133 P{?EP}Nup160^EP372M142 P{?EP}Nup160^EP372M161 P{?EP}Nup160^EP372M180 P{?EP}Nup160^EP372M185 P{?EP}Nup160^EP372M206 P{?EP}Nup160^EP372M215 P{?EP}Nup160^EP372M227 P{?EP}Nup160^EP372M230 P{?EP}Nup160^EP372M241 P{EP}Nup160^EP372 P{lacW}Nup160^SH2055 P{lacW}RfC38^k13807 PBac{RB}RfC38^e00704