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Reference Report
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| Citation | Sampson, C.J., Valanne, S., Fauvarque, M.O., Hultmark, D., Rämet, M., Williams, M.J. (2012). The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42. Dev. Comp. Immunol. 38(1): 160--168. (Export to RIS) | ||
| FlyBase ID | FBrf0219019 | ||
| Publication Type | Research paper | ||
| PubMed ID | 22634526 | ||
| PubMed Abstract | Zizimin-related (Zir), a Rho guanine nucleotide exchange factor (RhoGEF) homologous to the mammalian Dock-C/Zizimin-related family, was identified in a screen to find new genes involved in the Drosophila melanogaster cellular immune response against eggs from the parasitoid wasp Leptopilina boulardi. RhoGEFs activate Rho-family GTPases, which are known to be central regulators of cell migration, spreading and polarity. When a parasitoid wasp is recognized as foreign, multiple layers of circulating immunosurveillance cells (haemocytes) should attach to the egg. In Zir mutants this process is disrupted and lamellocytes, a haemocyte subtype, fail to properly encapsulate the wasp egg. Furthermore, macrophage-like plasmatocytes exhibit a strong reduction in their ability to phagocytise Escherichia coli and Staphylococcus aureus bacteria. During encapsulation and phagocytosis Zir genetically interacts with two Rho-family GTPases, Rac2 and Cdc42. Finally, Zir is dispensable for the humoral immune response against bacteria. We propose that Zir is necessary to activate the Rho-family GTPases Rac2 and Cdc42 during the Drosophila cellular immune response. | ||
| DOI | 10.1016/j.dci.2012.05.004 | ||
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| Language of Publication | English | ||
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Parent Publication
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| Publication Type | Journal | ||
| Abbreviation | Dev. Comp. Immunol. | ||
| Title | Developmental and Comparative Immunology | ||
| Publication Year | 1977- | ||
| ISBN/ISSN | 0145-305X | ||
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Data from Reference
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| Alleles (10)
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| Constructs (4)
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| Genes (10)
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| Insertions (2)
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