Reference Report

Reference
Citation	Wang, C.W., Sun, Y.H. (2012). Segregation of eye and antenna fates maintained by mutual antagonism in Drosophila. Development 139(18): 3413--3421. (Export to RIS)
FlyBase ID	FBrf0219201
Publication Type	Research paper
PubMed ID	22912416
PubMed Abstract	A general question in development is how do adjacent primordia adopt different developmental fates and stably maintain their distinct fates? In Drosophila melanogaster, the adult eye and antenna originate from the embryonic eye-antenna primordium. These cells proliferate in the larval stage to form the eye-antenna disc. The eye or antenna differs at mid second instar with the restricted expression of Cut (Ct), a homeodomain transcriptional repressor, in the antenna disc and Eyeless (Ey), a Pax6 transcriptional activator, in the eye disc. In this study, we show that ey transcription in the antenna disc is repressed by two homeodomain proteins, Ct and Homothorax (Hth). Loss of Ct and Hth in the antenna disc resulted in ectopic eye development in the antenna. Conversely, the Ct and Hth expression in the eye disc was suppressed by the homeodomain transcription factor Sine oculis (So), a direct target of Ey. Loss of So in the eye disc caused ectopic antenna development in the eye. Therefore, the segregation of eye and antenna fates is stably maintained by mutual repression of the other pathway.
DOI	10.1242/dev.078857
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Secondary IDs
Language of Publication	English
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Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Alleles (26)
	Avic\GFP^{ey.3.6.mcutx3+mhthx2} Avic\GFP^{ey.3.6.mcutx3} Avic\GFP^{ey.3.6.mhthx2} Avic\GFP^ey.3.6 Avic\GFP^eyg.PD.en Avic\GFP^{S65T.Scer\UAS} ct^C145 ct^{miRNA.Scer\UAS.cWa} ct^{miRNA.Scer\UAS} ct^Scer\UAS.cPa Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^ey.D02 Ecol\lacZ^so.10 ey^Scer\UAS.cHa hth^GD4741 hth^{miRNA.Scer\UAS} hth^Scer\UAS.cPa Scer\GAL4^dpp.blk1 Scer\GAL4^hth-GETDB Scer\GAL4^mirr-DE Scer\GAL4^{Scer\FRT.Act5C} Scer\GAL80^ts.αTub84B so¹ so³ toy^{miRNA.Scer\UAS.cWa} toy^{miRNA.Scer\UAS}
Constructs (20)
	P{AyGAL4} P{BS3.0} P{en-GFP.eyg.PD} P{ey3.6-GFP.mcutx3} P{ey3.6-GFP.mcutx3+mhthx2} P{ey3.6-GFP.mhthx2} P{ey3.6-GFP} P{ey-lacZ.D02} P{GAL4-dpp.blk1} P{GD4741} P{so-lacZ.10} P{tubP-GAL80^ts} P{UAS-ct.miRNA} P{UAS-ct.P} P{UAS-ey.H} P{UAS-GFP.S65T} P{UAS-hth.miRNA} P{UAS-hth.P} P{UAS-mi-toy-mi-cut} P{UAS-toy.miRNA}
Genes (15)
	Avic\GFP ct Dll dpp Ecol\lacZ elav en ey eya hth Scer\GAL4 Scer\GAL80 so toy wg
Insertions (2)
	P{GawB}hth^GETDB P{GawB}mirr^DE
Natural transposons (1)
	P-element