Reference Report

Reference
Citation	Senthilan, P.R., Piepenbrock, D., Ovezmyradov, G., Nadrowski, B., Bechstedt, S., Pauls, S., Winkler, M., Möbius, W., Howard, J., Göpfert, M.C. (2012). Drosophila auditory organ genes and genetic hearing defects. Cell 150(5): 1042--1054. (Export to RIS)
FlyBase ID	FBrf0219321
Publication Type	Research paper
PubMed ID	22939627
PubMed Abstract	The Drosophila auditory organ shares equivalent transduction mechanisms with vertebrate hair cells, and both are specified by atonal family genes. Using a whole-organ knockout strategy based on atonal, we have identified 274 Drosophila auditory organ genes. Only four of these genes had previously been associated with fly hearing, yet one in five of the genes that we identified has a human cognate that is implicated in hearing disorders. Mutant analysis of 42 genes shows that more than half of them contribute to auditory organ function, with phenotypes including hearing loss, auditory hypersusceptibility, and ringing ears. We not only discover ion channels and motors important for hearing, but also show that auditory stimulus processing involves chemoreceptor proteins as well as phototransducer components. Our findings demonstrate mechanosensory roles for ionotropic receptors and visual rhodopsins and indicate that different sensory modalities utilize common signaling cascades.
DOI	10.1016/j.cell.2012.06.043
Related Publication(s)
Note	Sensory transduction: confusing the senses. Kirkwood and Albert, 2013, Curr. Biol. 23(1): R22--R23 [FBrf0220506]
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (1)
	Df(3R)p13
Alleles (57)
	Ank2^f02001 Arr2⁵ ato¹ Bmcp^BG02446 bw¹ Cam⁵ Camⁿ³³⁹ CG4329^MB01614 CG6053^MB06262 CG6499^EY21789 CG8086^f03214 CG8419^MB06410 CG9313^Z2-5863 CG9492^KG02504 CG11253^EY10866 CG14636^MB03866 CG14693^f03110 CG14921^C247 Dhc36C^LA00085 Dhc93AB^MB05444 eya² futsch^K68 gl³ gol^MB03006 inaD^T1 Ir64a^MB05283 Ir75a^MB00253 Ir94b^MB02190 kek4^MB11415 Klp68D^EY00199 Naam^KG10548 ninaC^MB02664 norpA⁷ rdgA¹ Rh5² Rh6¹ Rh6^+t2.6 santa-maria¹ santa-maria^Scer\UAS.cWa Scer\GAL4^CG4329.PS Scer\GAL4^CG9313.PS Scer\GAL4^CG11253.PS Scer\GAL4^CG13636.PS Scer\GAL4^CG14921.PS Scer\GAL4^Dhc93AB.PS Scer\GAL4^Ir94b.PS Scer\GAL4^Klp68D.PS Scer\GAL4^Naam.PS Scer\GAL4^ph-p-NP0761 sei^HP21840 sosie^MB03846 stops¹ Sulf1^MB11661 trp¹ trpl³⁰² wtrw^E754K yuri^PL00114
Constructs (11)
	P{CG4329-GAL4.S} P{CG9313-GAL4.S} P{CG11253-GAL4.S} P{CG13636-GAL4.S} P{CG14921-GAL4.S} P{Dhc93AB-GAL4.S} P{Ir94b-GAL4.S} P{Klp68D-GAL4.S} P{Naam-GAL4.S} P{Rh6^+t2.6} P{UAS-santa-maria.W}
Genes (108)
	Ank2 Arr2 ato B52 Bmcp boss bsk bw cac Calx Cam CAP CdsA Cep97 CG3339 CG4329 CG5280 CG6053 CG6499 CG7568 CG7971 CG8086 CG8407 CG8419 CG8800 CG9279 CG9313 CG9492 CG9935 CG11253 CG13133 CG13855 CG13889 CG14015 CG14185 CG14636 CG14693 CG14905 CG14921 CG16789 CG17378 CG17669 CG18130 CG18516 CG31291 CG32373 CG33061 CG34297 Dhc16F Dhc36C Dhc93AB dlg1 dtr Eaat2 eya eys faf futsch gl gol Gβ76C Gγ30A Hdc HisCl1 iav inaC inaD Ir8a Ir64a Ir75a Ir75d Ir76a Ir94b Ir100a kek4 king-tubby Klp68D laza MESK2 Naam nan ninaA ninaC norpA Os-C rdgA rdgC Rh3 Rh4 Rh5 Rh6 rtp santa-maria Scer\GAL4 se sei Sh sosie stj stops Sulf1 Tektin-C tilB tipE trp trpl wtrw yuri
Insertions (1)
	P{GawB}ph-p^NP0761
Natural transposons (1)
	P-element
Transcripts (9)
	Scer\GAL4^CG4329.PSRA Scer\GAL4^CG9313.PSRA Scer\GAL4^CG11253.PSRA Scer\GAL4^CG13636.PSRA Scer\GAL4^CG14921.PSRA Scer\GAL4^Dhc93AB.PSRA Scer\GAL4^Ir94b.PSRA Scer\GAL4^Klp68D.PSRA Scer\GAL4^Naam.PSRA