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Citation
Senthilan, P.R., Piepenbrock, D., Ovezmyradov, G., Nadrowski, B., Bechstedt, S., Pauls, S., Winkler, M., Möbius, W., Howard, J., Göpfert, M.C. (2012). Drosophila auditory organ genes and genetic hearing defects.  Cell 150(5): 1042--1054.
FlyBase ID
FBrf0219321
Publication Type
Research paper
Abstract

The Drosophila auditory organ shares equivalent transduction mechanisms with vertebrate hair cells, and both are specified by atonal family genes. Using a whole-organ knockout strategy based on atonal, we have identified 274 Drosophila auditory organ genes. Only four of these genes had previously been associated with fly hearing, yet one in five of the genes that we identified has a human cognate that is implicated in hearing disorders. Mutant analysis of 42 genes shows that more than half of them contribute to auditory organ function, with phenotypes including hearing loss, auditory hypersusceptibility, and ringing ears. We not only discover ion channels and motors important for hearing, but also show that auditory stimulus processing involves chemoreceptor proteins as well as phototransducer components. Our findings demonstrate mechanosensory roles for ionotropic receptors and visual rhodopsins and indicate that different sensory modalities utilize common signaling cascades.

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Obtained with permission from Cell Press.
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PubMed Central ID
Related Publication(s)
Note

Sensory transduction: confusing the senses.
Kirkwood and Albert, 2013, Curr. Biol. 23(1): R22--R23 [FBrf0220506]

A cornucopia of candidates for deafness.
Lewis and Steel, 2012, Cell 150(5): 879--881 [FBrf0219319]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Aberrations (1)
    Alleles (57)
    Genes (108)
    Human Disease Models (4)
    Natural transposons (1)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (11)
    Transcripts (9)