Reference Report

Reference
Citation	Susic-Jung, L., Hornbruch-Freitag, C., Kuckwa, J., Rexer, K.H., Lammel, U., Renkawitz-Pohl, R. (2012). Multinucleated smooth muscles and mononucleated as well as multinucleated striated muscles develop during establishment of the male reproductive organs of Drosophila melanogaster. Dev. Biol. 370(1): 86--97. (Export to RIS)
FlyBase ID	FBrf0219326
Publication Type	Research paper
PubMed ID	22841645
PubMed Abstract	The adult musculature in D. melanogaster forms during metamorphosis. Much is known about the flight and leg musculature, but not about the muscles surrounding the male reproductive tract. The inner genitalia of males consist of the testes, which emerge from the gonads; the remaining genital organs, i.e., paragonia (or accessory glands), ejaculatory duct, sperm pump, and seminal vesicles, develop out of the genital imaginal disc. We analyzed the myoblasts forming the muscle layers of these organs. In myoblasts derived from the genital imaginal disc, the regulatory region of the transcription factor DMef2 is active. DMef2 is also needed for specification and differentiation of embryonic and adult myoblasts. We could discriminate three different muscle types: (i) multinucleated muscles that resemble vertebrate smooth muscles surround the testes, (ii) multinucleated muscles that resemble striated muscles comprises seminal vesicles and the sperm pump, and (iii) mononucleated striated musculature encloses the paragonia and ejaculatory duct. Members of the immunoglobulin superfamily involved in embryonic myogenesis, Dumbfounded (Duf) and Sticks and Stones (Sns), were also expressed in the genital imaginal disc, in the muscle sheath of the testes during muscle differentiation and in the secretory secondary cells, which are part of the binucleated epithelia enclosing the paragonia.
DOI	10.1016/j.ydbio.2012.07.022
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (13)
	Avic\GFP^{S65T.Scer\UAS} Avic\GFP^sls-ZCL2144 Avic\GFP^trol-GFP311 Disc\RFP^{mCherry.sns.T:nls-tra} hbs^GD2566 kirre^GD2595 rst^GD86 rst^JF03087 Scer\GAL4^C855a Scer\GAL4^kirre-rP298 Scer\GAL4^Mef2.PR Scer\GAL4^sns.PS sns^KK108577
Constructs (10)
	P{GAL4-Mef2.R} P{GD86} P{GD2566} P{GD2595} P{KK108577} P{sns-GAL4.S} P{sns-mCherry.NLS} P{TRiP.JF03087} P{UAS-GFP.S65T} P{unk}
Genes (10)
	Avic\GFP Disc\RFP hbs kirre Mef2 rst Scer\GAL4 sls sns trol
Insertions (4)
	P{GAL4}rP298 P{GawB}C855a P{PTT-un1}sls^ZCL2144 P{unk}trol^GFP311
Natural transposons (1)
	P-element