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Citation
Takács, S., Biessmann, H., Reddy, H.M., Mason, J.M., Török, T. (2012). Protein interactions on telomeric retrotransposons in Drosophila.  Int. J. Biol. Sci. 8(7): 1055--1061.
FlyBase ID
FBrf0219367
Publication Type
Research paper
Abstract
Telomere length in Drosophila is maintained by targeted transposition of three non-LTR retrotransposons: HeT-A, TART and TAHRE (HTT), but understanding the regulation of this process is hindered by our poor knowledge of HTT associated proteins. We have identified new protein components of the HTT array: Chromator (Chro), the TRF2/DREF complex and the sumoylation machinery. Chro was localized on telomeric HTT arrays by immunostaining, where it may interact with Prod directly, as indicated by yeast two-hybrid interaction, co-IP, and colocalization on polytene chromosomes. The TRF2/DREF complex may promote the open structure of HTT chromatin. The protein interactions controlling HTT chromatin structure and telomere length may be modulated by sumoylation.
PubMed ID
PubMed Central ID
PMC3432853 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Int. J. Biol. Sci.
    Title
    International Journal of Biological Sciences
    Publication Year
    2004-
    ISBN/ISSN
    1449-2288
    Data From Reference
    Genes (23)
    Physical Interactions (5)
    Cell Lines (2)
    Natural transposons (1)