Reference Report

Reference
Citation	Rynes, J., Donohoe, C.D., Frommolt, P., Brodesser, S., Jindra, M., Uhlirova, M. (2012). Activating transcription factor 3 regulates immune and metabolic homeostasis. Mol. Cell. Biol. 32(19): 3949--3962. (Export to RIS)
FlyBase ID	FBrf0219385
Publication Type	Research paper
PubMed ID	22851689
PubMed Abstract	Integration of metabolic and immune responses during animal development ensures energy balance, permitting both growth and defense. Disturbed homeostasis causes organ failure, growth retardation, and metabolic disorders. Here, we show that the Drosophila melanogaster activating transcription factor 3 (Atf3) safeguards metabolic and immune system homeostasis. Loss of Atf3 results in chronic inflammation and starvation responses mounted primarily by the larval gut epithelium, while the fat body suffers lipid overload, causing energy imbalance and death. Hyperactive proinflammatory and stress signaling through NF-κB/Relish, Jun N-terminal kinase, and FOXO in atf3 mutants deregulates genes important for immune defense, digestion, and lipid metabolism. Reducing the dose of either FOXO or Relish normalizes both lipid metabolism and gene expression in atf3 mutants. The function of Atf3 is conserved, as human ATF3 averts some of the Drosophila mutant phenotypes, improving their survival. The single Drosophila Atf3 may incorporate the diversified roles of two related mammalian proteins.
DOI	10.1128/MCB.00429-12
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Cell. Biol.
Title	Molecular and Cellular Biology
Publication Year	1981-
ISBN/ISSN	0270-7306
Data from Reference
Alleles (15)
	Atf3⁷⁶ Atf3^{CH321-51N24.T:Avic\GFP-EGFP} Atf3^Scer\UAS.cSa Avic\GFP^S65T.AttA Ecol\lacZ^puc-E69 foxo^25J13 foxo^Δ94 Hsap\ATF3^{Scer\UAS.T:Zzzz\FLAG} Ppyr\LUC^Drs.PB Rel^{68.Scer\UAS.T:Zzzz\FLAG} Rel^E20 Scer\GAL4^C7 Scer\GAL4^da.G32 Scer\GAL4^fat T:Avic\GFP^EGFP
Constructs (6)
	M{Atf3-EGFP.CH321-51N24} P{AttA-GFP.JL166} P{Drs-LUC.B} P{GAL4} P{UAS-Atf3.S} P{UAS-hATF3.FLAG}
Genes (100)
	Akap200 arm Atf3 AttA AttB AttC AttD Avic\GFP CG3902 CG4729 CG5550 CG5883 CG5966 CG6271 CG6283 CG6295 CG6933 CG6996 CG7798 CG10140 CG11425 CG11426 CG13075 CG13422 CG13806 CG14645 CG14957 CG15829 CG17826 CG18278 CG30059 CG31089 CG32284 CG32302 CG33470 Cht4 Cht5 Ddc Dif Dl dos Drs Drsl2 Drsl5 Dys Ecol\lacZ fa2h Fadd fon foxo Gadd45 GNBP2 Hsap\ATF3 IM1 IM2 IM3 IM4 IM10 IM23 Jra Lip3 Lip4 LysB LysC LysD LysE mtg Muc18B Muc26B Muc68E NijA NLaz obst-G obst-H obst-J p38c Pepck PGRP-LA PGRP-LF PGRP-SC1a PGRP-SC1b PGRP-SC2 PGRP-SD Phk-3 Ppyr\LUC puc Pvf1 Rel santa-maria Scer\GAL4 sn Sr-CIV T:Zzzz\FLAG Thor TM9SF4 TotA TotC Vago wun βTub60D
Insertions (3)
	P{A92}puc^E69 P{GAL4}C7 P{GAL4}fat
Natural transposons (2)
	Dmau\mariner P-element