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Citation
Bryantsev, A.L., Duong, S., Brunetti, T.M., Chechenova, M.B., Lovato, T.L., Nelson, C., Shaw, E., Uhl, J.D., Gebelein, B., Cripps, R.M. (2012). Extradenticle and homothorax control adult muscle fiber identity in Drosophila.  Dev. Cell 23(3): 664--673.
FlyBase ID
FBrf0219427
Publication Type
Research paper
Abstract
Here we identify a key role for the homeodomain proteins Extradenticle (Exd) and Homothorax (Hth) in the specification of muscle fiber fate in Drosophila. exd and hth are expressed in the fibrillar indirect flight muscles but not in tubular jump muscles, and manipulating exd or hth expression converts one muscle type into the other. In the flight muscles, exd and hth are genetically upstream of another muscle identity gene, salm, and are direct transcriptional regulators of the signature flight muscle structural gene, Actin88F. Exd and Hth also impact muscle identity in other somatic muscles of the body by cooperating with Hox factors. Because mammalian orthologs of exd and hth also contribute to muscle gene regulation, our studies suggest that an evolutionarily conserved genetic pathway determines muscle fiber differentiation.
PubMed ID
PubMed Central ID
PMC3575643 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference