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Stinchfield, M.J., Takaesu, N.T., Quijano, J.C., Castillo, A.M., Tiusanen, N., Shimmi, O., Enzo, E., Dupont, S., Piccolo, S., Newfeld, S.J. (2012). Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient.  Development 139(15): 2721--2729.
FlyBase ID
FBrf0219593
Publication Type
Research paper
Abstract
The ability of secreted Transforming Growth Factor β (TGFβ) proteins to act as morphogens dictates that their influence be strictly regulated. Here, we report that maternally contributed fat facets (faf; a homolog of USP9X/FAM) is essential for proper interpretation of the zygotic Decapentaplegic (Dpp) morphogen gradient that patterns the embryonic dorsal-ventral axis. The data suggest that the loss of faf reduces the activity of Medea (a homolog of Smad4) below the minimum necessary for adequate Dpp signaling and that this is likely due to excessive ubiquitylation on a specific lysine. This study supports the hypothesis that the control of cellular responsiveness to TGFβ signals at the level of Smad4 ubiquitylation is a conserved mechanism required for proper implementation of a morphogen gradient.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
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