Reference Report

Reference
Citation	Poels, J., Spasic, M.R., Callaerts, P., Norga, K.K. (2012). An appetite for destruction: From self-eating to cell cannibalism as a neuronal survival strategy. Autophagy 8(9): 1401--1403. (Export to RIS)
FlyBase ID	FBrf0219603
Publication Type	Note
PubMed ID	22885706
PubMed Abstract	Autophagy plays an important role in cellular survival by resupplying cells with nutrients during starvation or by clearing misfolded proteins and damaged organelles and thereby preventing degenerative diseases. Conversely, the autophagic process is also recognized as a cellular death mechanism. The circumstances that determine whether autophagy has a beneficial or a detrimental role in cellular survival are currently unclear. We recently showed that autophagy induction is detrimental in neurons that lack a functional AMPK enzyme (AMP-activated protein kinase) and that suffer from severe metabolic stress. We further demonstrated that autophagy and AMPK are interconnected in a negative feedback loop that prevents excessive and destructive stimulation of the autophagic process. Finally, we uncovered a new survival mechanism in AMPK-deficient neurons--cell cannibalism.
DOI	10.4161/auto.21052
Related Publication(s)
Research paper	Autophagy and phagocytosis-like cell cannibalism exert opposing effects on cellular survival during metabolic stress. Poels et al., 2012, Cell Death Differ. 19(10): 1590--1601 [FBrf0219353]
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Autophagy
Title	Autophagy
Publication Year	2005-
ISBN/ISSN	1554-8627 1554-8635
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