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Citation
Koles, K., Budnik, V. (2012). Wnt signaling in neuromuscular junction development.  Cold Spring Harbor Perspect. Biol. 4(6): .
FlyBase ID
FBrf0219664
Publication Type
Review
Abstract
Wnt proteins are best known for their profound roles in cell patterning, because they are required for the embryonic development of all animal species studied to date. Besides regulating cell fate, Wnt proteins are gaining increasing recognition for their roles in nervous system development and function. New studies indicate that multiple positive and negative Wnt signaling pathways take place simultaneously during the formation of vertebrate and invertebrate neuromuscular junctions. Although some Wnts are essential for the formation of NMJs, others appear to play a more modulatory role as part of multiple signaling pathways. Here we review the most recent findings regarding the function of Wnts at the NMJ from both vertebrate and invertebrate model systems.
PubMed ID
PubMed Central ID
PMC3367558 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cold Spring Harbor Perspect. Biol.
    Title
    Cold Spring Harbor perspectives in biology
    ISBN/ISSN
    1943-0264
    Data From Reference
    Genes (8)