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Voßfeldt, H., Butzlaff, M., Prüßing, K., Ní Chárthaigh, R.A., Karsten, P., Lankes, A., Hamm, S., Simons, M., Adryan, B., Schulz, J.B., Voigt, A. (2012). Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila.  PLoS ONE 7(11): e47452.
FlyBase ID
FBrf0219927
Publication Type
Research paper
Abstract
Polyglutamine (polyQ) diseases represent a neuropathologically heterogeneous group of disorders. The common theme of these disorders is an elongated polyQ tract in otherwise unrelated proteins. So far, only symptomatic treatment can be applied to patients suffering from polyQ diseases. Despite extensive research, the molecular mechanisms underlying polyQ-induced toxicity are largely unknown. To gain insight into polyQ pathology, we performed a large-scale RNAi screen in Drosophila to identify modifiers of toxicity induced by expression of truncated Ataxin-3 containing a disease-causing polyQ expansion. We identified various unknown modifiers of polyQ toxicity. Large-scale analysis indicated a dissociation of polyQ aggregation and toxicity.
PubMed ID
PubMed Central ID
PMC3489908 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS ONE
    Title
    PLoS ONE
    Publication Year
    2006-
    ISBN/ISSN
    1932-6203
    Data From Reference
    Alleles (74)
    Genes (72)
    Human Disease Models (2)
    Insertions (1)
    Transgenic Constructs (74)